Abstract
Background/Objectives:
The quantitative impact of weight gain on prediabetic glucose dysregulation remains unknown; only one study quantitated the impact of weight loss. We quantified the impact of weight gain on the evolution and regression of prediabetes (PDM).
Subjects/Methods:
In 4234 subjects without diabetes, using logistic regression analysis with a 4.8-year follow-up period, we analyzed the relationship between (1) δBMI (BMIfollow-up−basal) and the progression from normal glucose regulation (NGR) to PDM or diabetes, and (2) δBMI and the regression from PDM to NGR.
Results:
Mean (±s.d.) δBMI was 0.17 (±1.3) kg/m2 in subjects with NGR and δBMI was positively and independently related to progression (adjusted odds ratio (ORadj) (95% CI), 1.24 (1.15–1.34), P<0.01). Mean (±s.d.) δBMI was −0.03 (±1.25) kg/m2 in those with PDM and δBMI was negatively related to the regression (ORadj, 0.72 (0.65–0.80), P<0.01). The relation of δBMI to the progression was significant in men (ORadj, 1.42 (1.28–1.59), P<0.01) but not in women (ORadj, 1.05 (0.94–1.19), P=0.36). Also, the negative impact of δBMI on the regression was significant only in men (men, ORadj, 0.65 (0.57–0.75), P<0.01; women, ORadj, 0.94 (0.77–1.14), P=0.51).
Conclusions:
In Japanese adults, an increase in the BMI by even 1 kg/m2 was related to 24% increase in the risk of development of PDM or diabetes in NGR subjects and was related to 28% reduction in the regression from PDM to NGR. In women, we did not note any significant impact of weight gain on the evolution or regression of PDM.
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Nakasone, Y., Miyakoshi, T., Sato, Y. et al. Impact of weight gain on the evolution and regression of prediabetes: a quantitative analysis. Eur J Clin Nutr 71, 206–211 (2017). https://doi.org/10.1038/ejcn.2016.118
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DOI: https://doi.org/10.1038/ejcn.2016.118
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