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Minerals, trace elements, Vit. D and bone health

Assessment of vitamin D status and serum CrossLaps levels in adults with primary lactose malabsorption

European Journal of Clinical Nutrition volume 70, pages 1000–1003 (2016)Cite this article

Subjects

Abstract

Background/Objectives:

Primary adult-type lactose malabsorption (PALM) is a widespread inherited autosomal recessive condition, which is considered to be associated with osteoporosis. This prospective study aimed at assessing the 25-hydroxy-vitamin D (25(OH)D) status and serum CrossLaps levels in individuals with PALM and normal controls.

Subjects/Methods:

All participants (n=210) underwent genotyping for the LCT C/T-13910 polymorphism, 25(OH)D and CrossLaps measurements and clinical examinations. In addition, the anthropometric data (that is, height, weight and body mass index) were determined.

Results:

Fifty-five individuals with PALM (that is, LCT C/C-13910 homozygotes) showed lower 25(OH)D (mean: 24.95±10.04 vs 28.59±9.56 ng/ml, P=0.018) and higher CrossLaps serum levels (mean: 0.46±0.31 vs 0.43±0.49 ng/ml, P=0.251) compared with 155 normal controls (that is, LCT C/T-13910 hetero- or T/T-13910 homozygotes). Anthropometric data were similar between PALM probands and controls.

Conclusions:

Individuals with PALM were found to have lower 25(OH)D and higher CrossLaps serum levels compared with normal controls. In order to preserve life-long bone health, routine 25(OH)D and CrossLaps serum measurements should be performed in individuals with PALM.

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Authors and Affiliations

  1. Institute of Clinical Chemistry and Laboratory Medicine, General Hospital Steyr, Steyr, Austria

    D Enko, G Kriegshäuser, R Stolba & G Halwachs-Baumann

  2. Clinical Institute of Medical and Laboratory Diagnostics, Medical University of Graz, Graz, Austria

    H Mangge

  3. University of Applied Sciences for Health Professions Upper Austria, Bachelor Programme Biomedical Science, General Hospital Steyr, Steyr, Austria

    D Brandstetter

  4. University of Applied Sciences for Health Professions Upper Austria, Bachelor Programme Dietetics, General Hospital Elisabethinen Linz, Linz, Austria

    N Mayr

  5. Department of Applied Systems Research and Statistics, Johannes Kepler University Linz, Linz, Austria

    T Forstner

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  1. D Enko
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  8. G Halwachs-Baumann
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Correspondence to D Enko.

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Enko, D., Kriegshäuser, G., Stolba, R. et al. Assessment of vitamin D status and serum CrossLaps levels in adults with primary lactose malabsorption. Eur J Clin Nutr 70, 1000–1003 (2016). https://doi.org/10.1038/ejcn.2016.66

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  • DOI: https://doi.org/10.1038/ejcn.2016.66

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