Abstract
Metalloproteinases (MMP) produced by both cancer and normal stromal fibroblast cells play a critical role in the metastatic spread of tumours, however little is known of the regulation of their release. In this report we demonstrate that breast cancer cells in culture release apparently full length soluble EMMPRIN that promotes the release of pro-MMP2 from fibroblasts. The generation of MMP2 is mediated by activation of phospholipase A2 and 5-lipoxygenase. These results suggest that the production of soluble EMMPRIN, phospholipase A2 and 5-lipoxygenase activities are sites for potential therapeutic intervention.
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This work was supported by Cancer Research UK and The Wellcome Trust, MN Hodgkin was a Beit Memorial Research Fellow.
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Taylor, P., Woodfield, R., Hodgkin, M. et al. Breast cancer cell-derived EMMPRIN stimulates fibroblast MMP2 release through a phospholipase A2 and 5-lipoxygenase catalyzed pathway. Oncogene 21, 5765–5772 (2002). https://doi.org/10.1038/sj.onc.1205702
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DOI: https://doi.org/10.1038/sj.onc.1205702
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