Interaction with heterotrimeric G proteins is a hallmark of G-protein-coupled receptor (GPCR) family members, and it is the key step for a diverse range of cell-signaling cascades. A recent cryo-EM structure of the human calcitonin receptor (CTR) in complex with a G-protein heterotrimer reveals novel insights into receptor–G-protein coupling.
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Acknowledgements
The research program in A.K.S.'s laboratory is supported by the Wellcome Trust DBT India Alliance (IA/I/14/1/501285), the Department of Biotechnology (DBT), the Department of Science and Technology (DST), the Council for Scientific and Industrial Research (CSIR) and the Institute of Technology, Kanpur.
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Baidya, M., Dwivedi, H. & Shukla, A. Frozen in action: cryo-EM structure of a GPCR–G-protein complex. Nat Struct Mol Biol 24, 500–502 (2017). https://doi.org/10.1038/nsmb.3418
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DOI: https://doi.org/10.1038/nsmb.3418
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