Treatment with liraglutide (3.0 mg once daily for 3 years), a glucagon-like peptide 1 receptor agonist that lowers levels of glucose and reduces body weight, reduced the risk of 'on treatment' type 2 diabetes mellitus (T2DM) versus placebo in patients with prediabetes and obesity. Whether this treatment affects the natural history of the progression from prediabetes to T2DM remains to be established.
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Within the past 36 months, T.V. has served on scientific advisory panels and/or speaker's bureaus for, served as a consultant to and/or received research support from Amgen, AstraZeneca, Boehringer, Bristol-Myers Squibb, Eli Lilly, Merck Sharp & Dohme, Novo Nordisk and Sanofi. Within the past 36 months, F.K.K. has served on scientific advisory panels and/or speaker's bureaus for, served as a consultant to and/or received research support from Amgen, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Fractyl, Gubra, Merck Sharp & Dohme, Novo Nordisk, Sanofi and Zealand Pharma.
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Vilsbøll, T., Knop, F. Liraglutide — preventing or postponing T2DM diagnosis?. Nat Rev Endocrinol 13, 320–322 (2017). https://doi.org/10.1038/nrendo.2017.55
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DOI: https://doi.org/10.1038/nrendo.2017.55