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Liraglutide — preventing or postponing T2DM diagnosis?

Treatment with liraglutide (3.0 mg once daily for 3 years), a glucagon-like peptide 1 receptor agonist that lowers levels of glucose and reduces body weight, reduced the risk of 'on treatment' type 2 diabetes mellitus (T2DM) versus placebo in patients with prediabetes and obesity. Whether this treatment affects the natural history of the progression from prediabetes to T2DM remains to be established.

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References

  1. Masters, R. K. et al. The impact of obesity on US mortality levels: the importance of age and cohort factors in population estimates. Am. J. Public Health 103, 1895–1901 (2013).

    Article  Google Scholar 

  2. The American Society for Metabolic and Bariatric Surgery, The Obesity Society, The American Society of Bariatric Physicians and American Association of Clinical Endocrinologists. Obesity is a disease: leading obesity groups agree. PR Newswire http://www.prnewswire.com/news-releases/obesity-is-a-disease-leading-obesity-groups-agree-212194851.html (2013).

  3. Knowler, W. C. et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N. Engl. J. Med. 346, 393–403 (2002).

    Article  CAS  Google Scholar 

  4. Tabák, A. G., Herder, C., Rathmann, W., Brunner, E. J. & Kivimäki, M. Prediabetes: a high-risk state for diabetes development. Lancet 379, 2279–2290 (2012).

    Article  Google Scholar 

  5. Khera, R. et al. Association of pharmacological treatments for obesity with weight loss and adverse events: a systematic review and meta-analysis. JAMA 315, 2424–2434 (2016).

    Article  CAS  Google Scholar 

  6. Lund, A., Knop, F. K. & Vilsbøll, T. Glucagon-like peptide-1 receptor agonists for the treatment of type 2 diabetes: differences and similarities. Eur. J. Intern. Med. 25, 407–414 (2014).

    Article  CAS  Google Scholar 

  7. Blonde, L. & Russell-Jones, D. The safety and efficacy of liraglutide with or without oral antidiabetic drug therapy in type 2 diabetes: an overview of the LEAD 1–5 studies. Diabetes Obes. Metab. 11 (Suppl. 3), 26–34 (2009).

    Article  CAS  Google Scholar 

  8. Wadden, T. A. et al. Weight maintenance and additional weight loss with liraglutide after low-calorie-diet-induced weight loss: the SCALE Maintenance randomized study. Int. J. Obes. (Lond.) 37, 1443–1451 (2013).

    Article  CAS  Google Scholar 

  9. le Roux, C. W. et al. 3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial. Lancet 389, 1399–1409 (2017).

    Article  CAS  Google Scholar 

  10. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 33 (Suppl. 1), S62–S69 (2010).

Download references

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Correspondence to Tina Vilsbøll.

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Competing interests

Within the past 36 months, T.V. has served on scientific advisory panels and/or speaker's bureaus for, served as a consultant to and/or received research support from Amgen, AstraZeneca, Boehringer, Bristol-Myers Squibb, Eli Lilly, Merck Sharp & Dohme, Novo Nordisk and Sanofi. Within the past 36 months, F.K.K. has served on scientific advisory panels and/or speaker's bureaus for, served as a consultant to and/or received research support from Amgen, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Fractyl, Gubra, Merck Sharp & Dohme, Novo Nordisk, Sanofi and Zealand Pharma.

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Vilsbøll, T., Knop, F. Liraglutide — preventing or postponing T2DM diagnosis?. Nat Rev Endocrinol 13, 320–322 (2017). https://doi.org/10.1038/nrendo.2017.55

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