Two studies in this issue show that the protein MeCP2, which is implicated in Rett syndrome, also critically regulates behavioral responses to psychostimulants. Although the two studies highlight different mechanisms of MeCP2 in regulating these behaviors, both underscore the importance of epigenetic mechanisms in establishing drug addiction.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
MeCP2 and the enigmatic organization of brain chromatin. Implications for depression and cocaine addiction
Clinical Epigenetics Open Access 21 May 2016
-
Decitabine alters the expression of Mecp2 isoforms via dynamic DNA methylation at the Mecp2 regulatory elements in neural stem cells
Molecular Autism Open Access 15 November 2013
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Marina Corral
References
Nestler, E.J. Nat. Rev. Neurosci. 2, 119–128 (2001).
Deng, J.V. et al. Nat. Neurosci. 13, 1128–1136 (2010).
Im, H. et al. Nat. Neurosci. 13, 1120–1127 (2010).
Chahrour, M. & Zoghbi, H.Y. Neuron 56, 422–437 (2007).
Chen, W.G. et al. Science 302, 885–889 (2003).
Martinowich, K. et al. Science 302, 890–893 (2003).
Monteggia, L.M. & Kavalali, E.T. Biol. Psychiatry 65, 204–210 (2009).
Cassel, S. et al. Mol. Pharmacol. 70, 487–492 (2006).
Belin, D. et al. Behav. Brain Res. 199, 89–102 (2009).
Graham, D.L. et al. Nat. Neurosci. 10, 1029–1037 (2007).
Hollander, J.A. et al. Nature 466, 197–202 (2010).
Klein, M.E. et al. Nat. Neurosci. 10, 1513–1514 (2007).
LaPlant, Q. & Nestler, E.J. Horm. Behav. published online, doi:10.1016/j.yhbeh.2010.05.015 (4 June 2010).
Nikitina, T. et al. Mol. Cell. Biol. 27, 864–877 (2007).
Skene, P.J. et al. Mol. Cell 37, 457–468 (2010).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Feng, J., Nestler, E. MeCP2 and drug addiction. Nat Neurosci 13, 1039–1041 (2010). https://doi.org/10.1038/nn0910-1039
Issue Date:
DOI: https://doi.org/10.1038/nn0910-1039
This article is cited by
-
Cannabidiol inhibits methamphetamine-induced dopamine release via modulation of the DRD1-MeCP2-BDNF-TrkB signaling pathway
Psychopharmacology (2022)
-
Role of nucleus accumbens microRNA-181a and MeCP2 in incubation of heroin craving in male rats
Psychopharmacology (2021)
-
MeCP2 and the enigmatic organization of brain chromatin. Implications for depression and cocaine addiction
Clinical Epigenetics (2016)
-
Interactions between Early Life Stress, Nucleus Accumbens MeCP2 Expression, and Methamphetamine Self-Administration in Male Rats
Neuropsychopharmacology (2016)
-
Decitabine alters the expression of Mecp2 isoforms via dynamic DNA methylation at the Mecp2 regulatory elements in neural stem cells
Molecular Autism (2013)
