Genomics researcher Mark Eppinger was starting to crave stability. Since arriving in the United States in 2004 from his native Germany, Eppinger had completed a postdoc and a stint in industry, and had been working for five years at the University of Maryland in Baltimore in a non-tenure-track post. Newly married and with a baby, he wanted to find a permanent job, ideally a tenure-track academic position, and remain in the country.

Credit: SHUTTERSTOCK/MONGOLKA

But Eppinger was in his fifth year of an H-1B non-immigrant work visa, which expired in a year and could not be renewed — it has a maximum term of six years. Because he hoped to remain in the country indefinitely, Eppinger decided to apply for an immigrant visa that grants permanent-resident status in the United States to non-US citizens — the sought-after 'green card', so called because it used to be issued as an actual green card. After consulting colleagues who had successfully navigated the process, Eppinger applied for a self-sponsored green card in October 2011 to US Citizenship and Immigration Services (USCIS), the federal agency that adjudicates applications and issues immigrant visas. With the help of an immigration attorney, he filed his application under two of five categories available to those who are applying for an employment-based immigration visa (see 'Employer- or self-sponsorship').

Although there were no glitches and he received his green card with time to spare, Eppinger found the process stressful and time-consuming. The two categories under which he had applied — as an individual of 'extraordinary ability' ('Priority Worker'), and as an individual seeking a National Interest Waiver — each required substantial documentation of his professional achievements. In addition, he had to round up recommendation letters from half a dozen eminent researchers in his field. “That was the most difficult part,” Eppinger recalls. He pre-wrote each letter, focusing on different accomplishments, then waited to get them back. “It took so long,” Eppinger says. “Even though the letter's already written, you have to let people freely edit it.” Despite the anxiety, however, he is relieved to have the card. “You are way more flexible,” says Eppinger, now an assistant professor in microbial genomics at the University of Texas at San Antonio, a tenure-track position. “My wife and I knew we wanted to stay here — we have no intentions of going back to Germany — so going for the green card was a no-brainer.”

There are a daunting number of steps and a lot of documentation required to get a green card. But applicants can smooth their path by giving themselves ample time to understand the process, gather the necessary evidence, file paperwork and wait for application backlogs to clear.

The green card is highly sought after because researchers in the United States who hold any of the temporary, non-immigrant visas are limited in various ways. Waiting times for getting many of them can be six months or more (see Nature 460, 131–132; 2009). There is the 'home-residence' rule that requires some visa holders to return to their home country for two years after the visa expires. Some visas limit travel in and out of the United States; others allow the visa holder to work only for the employer that sponsored the visa. And temporary visas have set terms that vary from one to six years.

Deck of cards

As a permanent resident with a green card, Eppinger is now free from such worries. Green cards need to be renewed only once every 10 years and there are no limits on the number of renewals. And green-card holders can travel out of the United States for up to 179 days each year — a boon for researchers planning to attend foreign conferences or take part in international collaborations. A huge bonus for many is that having a green card confers the right to apply for all federal grants and fellowships, whereas those on non-immigrant visas are not eligible for some types of funding.

“If you're on a self-sponsored green card,” says immigration attorney Elizabeth Goss of Tocci, Goss & Lee in Boston, Massachusetts, “you can work for whomever you want or start your own company. You're not dependent on any employer to sponsor you for a visa. You don't have to be beholden to anyone.”

Green-card applicants can pursue an employment-based visa, which requires a certain level of skills, education and/or work experience, or a family-based visa, which requires sponsorship by a spouse or relative who is a US citizen or legal permanent resident. Once a researcher decides to apply for a green card, the next determination is the type of sponsorship to pursue. For employment-based applications, the options are employer sponsorship or self-sponsorship. Employer sponsorship requires a job offer or an existing position; in both cases, the applicant must expect to remain in that job for up to two years. If they leave that job within six months of getting the card, it may be revoked.

There are other restrictions to employer sponsorship: employers may choose to sponsor only particular positions, or only employees who will be in a particular position for a certain length of time. And employers may require an employee to work for some time before he or she becomes eligible for sponsorship. However, the employer generally organizes the process and must pay the processing fees and other expenses of the application, such as the cost of the required medical examination.

Many scientists, however, choose self-sponsorship, which does not depend on having a job or job offer. Immigration experts note other benefits: a self-sponsoring applicant can soon move to another job — as long as it's in the same field — or launch his or her own company.

The application steps for employer and self-sponsorship are very similar (see 'Securing the visa'). But anyone applying under the Priority Worker category (employment-based category 1, or EB-1) must prove that they have “extraordinary” abilities and are internationally renowned in their field. A doctorate or postdoc experience at an elite US university will not be sufficient. “You've got to show that you're one of the small percentage at the very top of your field,” says immigration attorney Brendan Delaney of Leavy, Frank & Delaney in Bethesda, Maryland, who, as a consultant for the US National Postdoctoral Association in Washington DC, works with many early-career researchers.

As a result, most early-career researchers opt for the National Interest Waiver subcategory of professionals with advanced degrees (EB-2). The other stages are as for an employer-sponsored application, but the applicant has the responsibility of providing all the information needed and of monitoring their application. After submitting an I-140, they receive their 'priority date' — their place in line for an immigrant visa number. Once the priority date is current and the I-140 is granted, the applicant must then file an I-485 — the final stage.

Evidence submitted at the I-140 stage of a self-sponsored application could include copies of published papers along with information on first or second authorship, the papers' citation indexes and the impact factor of the journals in which they appeared; records of interviews and conference talks, especially invited talks; peer review undertaken; patents filed, especially if in use or generating interest; and awards, grants and fellowships (see 'Gathering the evidence').

Beware the caveats

All these documents — along with a published book and grants in hand — were what it took for Dimitar Baronov, a Bulgarian native with a PhD from Boston University in Massachusetts, to secure a self-sponsored green card. The card was key to Baronov's plans, and in 2010 he co-founded Sterling Point Research in Boston, Massachusetts, which develops medical diagnostics. Baronov says that he has far more flexibility. “It would have been really hard to run this company if I were still a temporary-visa holder,” he says. “I can apply for federal grants, I have latitude for my research and I can create jobs.”

But applications don't come cheap. Self-sponsoring applicants who hire an immigration attorney — and immigration experts recommend doing that — will rack up legal and federal processing fees and other expenses of up to US$8,000.

There are other caveats. One is that green-card renewal, although usually routine, requires the holder to be free of certain criminal convictions. Some missteps, such as overstaying a previous visa, may render the applicant ineligible. Another sticking point is that trips out of the country beyond 179 days require USCIS re-entry permits, which provide for absences of up to two years. Scientists who travel outside of the country on collaborations or fieldwork for more than six months at a time should be aware that the USCIS might interpret those trips as abandonment of their US residence and move to deport them.

Opinions vary on the best time for an early-career researcher to pursue a green card. Some immigration experts say that it can take as long as eight years after a researcher's US career launch, depending on the quality of their publication and citation records.

Sadakatsu Ikeda: “Getting the right information was a big struggle in the very beginning.” Credit: E. BRONSON/MICHIGAN PHOTOGRAPHY

With so much riding on the card, a rush to apply can create anxiety. Hou-Sung Jung, a research assistant professor of plant biology at Dartmouth College in Hanover, New Hampshire, experienced this first-hand. The South Korea native spent seven years as a postdoc, mostly on an H-1B visa. Busy with his research, publications and a new marriage, he forgot about the visa's expiry date. He was able to assemble the documentation and materials for a green-card application within two months and received the card with a month to spare. “I was lucky,” says Jung.

Some immigration experts counsel that a researcher arriving in the United States on a temporary visa of any type should immediately start educating themselves on the process and details of acquiring the green card, even if they don't expect to want one. “If you leave things too late, you may find yourself in a position where you're running out of options,” says Delaney, who, as a native of Northern Ireland, has gone through the process himself.

Applicants may receive conflicting or inaccurate information from employers that steers them down the wrong path. “At the green-card centre at one university, the information on the process was so confusing,” says Sadakatsu Ikeda, a native of Japan who is a clinical fellow in haematology and oncology at the University of Michigan in Ann Arbor. “Different people told me different things.” Ultimately, he decided to pursue the self-sponsored route for the freedom to move to different employers and to control the process himself.

Shortly after starting a molecular biology and genetics postdoc at Harvard Medical School in Boston, Massachusetts, Ikeda hired an attorney who showed him how to apply under the National Interest Waiver subgroup and recommended that Ikeda work on publishing citable papers, building an extensive network of contacts and getting his name widely known in his field. By the time Ikeda began to pursue the application seven years later, after a three-year residency, he was first or second author on a number of papers in high-impact journals, had amassed a robust contacts network and was well known in cancer research. He had no trouble getting five letters of recommendation, and received his green card without any hassle six months later.

“Getting the right information was a big struggle in the very beginning, and building this network and my reputation — that was the biggest obstacle,” says Ikeda. “But in the end, I was successful because I had a good roadmap.”