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Foxp3 and Aire in thymus-generated Treg cells: a link in self-tolerance

Nature Immunology volume 8, pages 333–334 (2007)Cite this article

The transcriptional regulators Foxp3 and Aire have key functions in self-tolerance. New studies emphasize potential links between Aire-expressing thymic stromal cells and the development of Foxp3-expressing regulatory T cells.

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Figure 1: Interactions between developing thymocytes and thymic stromal cells, in particular Aire-expressing mTECs, may drive thymocytes into the Treg cell lineage.

Kim Caesar

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Authors and Affiliations

  1. Takashi Nomura and Shimon Sakaguchi are in the Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan. shimon@frontier.kyoto-u.ac.jp,

    Takashi Nomura & Shimon Sakaguchi

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  1. Takashi Nomura
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  2. Shimon Sakaguchi
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Nomura, T., Sakaguchi, S. Foxp3 and Aire in thymus-generated Treg cells: a link in self-tolerance. Nat Immunol 8, 333–334 (2007). https://doi.org/10.1038/ni0407-333

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