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Untangling Fc and complement receptors to kill tumors

Nature Immunology volume 18, pages 874–875 (2017)Cite this article

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Uncoupling of activation of Fc receptors via a mutant IgG1 Fc domain shows a direct role for complement receptors in antibody-dependent tumor killing.

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Figure 1: The various mechanisms by which antibodies can induce tumor killing.

Debbie Maizels/Springer Nature

References

  1. Lee, C.H. et al. Nat. Immunol. 18, 889–898 (2017).

    Article  CAS  Google Scholar 

  2. Cartron, G. et al. Blood 99, 754–758 (2002).

    Article  CAS  Google Scholar 

  3. Weng, W.K. & Levy, R. J. Clin. Oncol. 21, 3940–3947 (2003).

    Article  CAS  Google Scholar 

  4. Meyer, S., Leusen, J.H. & Boross, P. MAbs 6, 1133–1144 (2014).

    Article  Google Scholar 

  5. Biburger, M., Lux, A. & Nimmerjahn, F. Adv. Immunol. 124, 67–94 (2014).

    Article  Google Scholar 

  6. Bournazos, S. & Ravetch, J.V. Immunol. Rev. 268, 88–103 (2015).

    Article  CAS  Google Scholar 

  7. DiLillo, D.J. & Ravetch, J.V. Cancer Immunol. Res. 3, 704–713 (2015).

    Article  CAS  Google Scholar 

  8. Weiner, G.J. Nat. Rev. Cancer 15, 361–370 (2015).

    Article  CAS  Google Scholar 

  9. Hezareh, M., Hessell, A.J., Jensen, R.C., van de Winkel, J.G. & Parren, P.W. J. Virol. 75, 12161–12168 (2001).

    Article  CAS  Google Scholar 

  10. Idusogie, E.E. et al. J. Immunol. 166, 2571–2575 (2001).

    Article  CAS  Google Scholar 

  11. Bruhns, P. & Jönsson, F. Immunol. Rev. 268, 25–51 (2015).

    Article  CAS  Google Scholar 

  12. Bajic, G., Degn, S.E., Thiel, S. & Andersen, G.R. EMBO J. 34, 2735–2757 (2015).

    Article  CAS  Google Scholar 

  13. Teachey, D.T. et al. Blood 121, 5154–5157 (2013).

    Article  CAS  Google Scholar 

  14. Winkler, U. et al. Blood 94, 2217–2224 (1999).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Program in Cellular and Molecular Medicine, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, USA

    Cees E van der Poel & Michael C Carroll

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  1. Cees E van der Poel
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  2. Michael C Carroll
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Correspondence to Michael C Carroll.

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van der Poel, C., Carroll, M. Untangling Fc and complement receptors to kill tumors. Nat Immunol 18, 874–875 (2017). https://doi.org/10.1038/ni.3797

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