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Ontogeny and homeostasis of CNS myeloid cells

Nature Immunology volume 18, pages 385–392 (2017)Cite this article

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An Erratum to this article was published on 19 July 2017

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Abstract

Myeloid cells in the central nervous system (CNS) represent a heterogeneous class of innate immune cells that contribute to the maintenance of tissue homeostasis differentially during development and adulthood. The subsets of CNS myeloid cells identified so far, including parenchymal microglia and non-parenchymal meningeal, perivascular and choroid-plexus macrophages, as well as disease-associated monocytes, have classically been distinguished on the basis of their surface epitope expression, localization and morphology. However, studies using cell-specific targeting, in vivo imaging, single-cell expression analysis and other sophisticated tools have now increased the depth of knowledge of this immune-cell compartment and call for reevaluation of the traditional views on the origin, fate and function of distinct CNS myeloid subsets. The concepts of CNS macrophage biology that are emerging from these new insights have broad implications for the understanding and treatment of CNS diseases.

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Figure 1: Origin and turnover of tissue macrophages in healthy CNS.
Figure 2: The localization and genetic signature of CNS macrophages.
Figure 3: Myeloid-cell dysfunction in the adult CNS.

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  • 26 April 2017

    In the version of this article initially published, some of the arrows along the right side of Figure 1 were incorrect. The arrow from 'Ly6Chi monocyte' to 'pvMΦ long-living' should be deleted, and an arrow should be added from 'Ly6Chi monocyte' into the boxed area above (top right). The error has been corrected in the HTML and PDF versions of the article.

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Acknowledgements

We thank A. Parera and C. Groß for critical proofreading. Supported by the competence network of multiple sclerosis funded by Bundesministerium für Bildung und Forschung (M.P.), Sobek-Stiftung (M.P.), Deutsche Forschungsgemeinschaft (SFB 992, SFB1140, SFB/TRR167 and a Reinhart-Koselleck-Grant to M.P.; and SFB/TRR167 to D.E.) and the Faculty of Medicine of the University of Freiburg (Berta-Ottenstein-Programme; D.E.).

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  1. Daniel Erny and Nora Hagemeyer: These authors contributed equally to this work.

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  1. Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany

    Marco Prinz, Daniel Erny & Nora Hagemeyer

  2. BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg, Germany

    Marco Prinz

  3. Berta-Ottenstein-Programme, Faculty of Medicine, University of Freiburg, Freiburg, Germany

    Daniel Erny

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Prinz, M., Erny, D. & Hagemeyer, N. Ontogeny and homeostasis of CNS myeloid cells. Nat Immunol 18, 385–392 (2017). https://doi.org/10.1038/ni.3703

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