Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Manufacture of CAR-T cells in the body

Nature Biotechnology volume 35, pages 520–521 (2017)Cite this article

Subjects

Engineered T cells for cancer therapy are produced in the mouse bloodstream, avoiding the need to harvest T cells and manipulate them ex vivo.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: CAR-T-cell generation in situ or ex vivo.

Debbie Maizels/Springer Nature

References

  1. Smith, T.T. et al. Nat. Nanotechnol. (2017) 10.1038/nnano.2017.57.

  2. Khalil, D.N., Smith, E.L., Brentjens, R.J. & Wolchok, J.D. Nat. Rev. Clin. Oncol. 13, 394 (2016).

    Article  CAS  Google Scholar 

  3. Kebriaei, P. et al. J. Clin. Invest. 126, 3363–3376 (2016).

    Article  Google Scholar 

  4. Cox, D.B., Platt, R.J. & Zhang, F. Nat. Med. 21, 121–131 (2015).

    Article  CAS  Google Scholar 

  5. Ivics, Z. Mol. Ther. 24, 851–854 (2016).

    Article  CAS  Google Scholar 

  6. Klebanoff, C.A., Rosenberg, S.A. & Restifo, N.P. Nat. Med. 22, 26–36 (2016).

    Article  CAS  Google Scholar 

  7. Blankenstein, T., Leisegang, M., Uckert, W. & Schreiber, H. Curr. Opin. Immunol. 33, 112–119 (2015).

    Article  CAS  Google Scholar 

  8. Rosenberg, S.A. & Restifo, N.P. Science 348, 62–68 (2015).

    Article  CAS  Google Scholar 

  9. Schumacher, T.N. & Schreiber, R.D. Science 348, 69–74 (2015).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Johanna Olweus is at the Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet and K.G. Jebsen Center for Cancer Immunotherapy, University of Oslo, Oslo, Norway.,

    Johanna Olweus

Authors
  1. Johanna Olweus
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Johanna Olweus.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Olweus, J. Manufacture of CAR-T cells in the body. Nat Biotechnol 35, 520–521 (2017). https://doi.org/10.1038/nbt.3898

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt.3898

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research