Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • NEWS AND VIEWS

Location in the nucleus foretells chromosome anomalies

A single-cell analysis suggests that the 3D location of chromosomes in the cell nucleus contributes to their likelihood of being involved in genomic rearrangements associated with cancer.
  1. Krishnendu Guin

    1. Krishnendu Guin is at the National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

    View author publications

    You can also search for this author in PubMed  Google Scholar

  2. Tom Misteli

    1. Tom Misteli is at the National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

    View author publications

    You can also search for this author in PubMed  Google Scholar

Normal human cells have two copies of each chromosome. By contrast, many cancer cells have abnormal numbers of chromosomes, either having extra copies or lacking some. The most common reason for such abnormalities is the result of defective cell division, specifically, a failure to distribute the cell’s chromosomes equally between the two newly forming daughter cells. Writing in Nature, Klaasen et al.1 report that the 3D location of chromosomes in the nucleus before cell division affects their likelihood of being incorrectly partitioned in the daughter cells.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

Nature 607, 454-455 (2022)

doi: https://doi.org/10.1038/d41586-022-01865-y

References

  1. Klaasen, S. J. et al. Nature 607, 604–609 (2022).

    Article  Google Scholar 

  2. Takizawa, T., Meaburn, K. M. & Misteli, T. Cell 135, 9–13 (2008).

    Article  PubMed  Google Scholar 

  3. Crosetto, N. & Bienko, M. Front. Genet. 11, 33 (2020).

    Article  PubMed  Google Scholar 

  4. Ben-David, U. & Amon, A. Nature Rev. Genet. 21, 44–62 (2020).

    Article  PubMed  Google Scholar 

  5. Roukos, V. & Misteli, T. Nature Cell Biol. 16, 293–300 (2014).

    Article  PubMed  Google Scholar 

  6. Tang, Y.-C. & Amon, A. Cell 152, 394–405 (2013).

    Article  PubMed  Google Scholar 

Download references

Competing Interests

The authors declare no competing interests.

Subjects

Latest on:

Nature Careers

Jobs

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing

Search

Advanced search

Quick links