Abstract
T cells with Vβ3+αβ receptors are deleted by self-tolerance in mice with particular major histocompatibility complex/self-antigen combinations. This also occurs for other Vβ elements. Polymorphisms in the major histocompatibility complex and / or the self-antigens that cause massive deletion of T cells using particular Vβ elements may be maintained by the need to balance the advantage of a diverse T-cell repertoire against the potential involvement of those elements in autoimmune disease.
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Pullen, A., Marrack, P. & Kappler, J. The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens. Nature 335, 796–801 (1988). https://doi.org/10.1038/335796a0
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DOI: https://doi.org/10.1038/335796a0
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