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Immunotherapy has proven effective in treating multiple diseases, most notably cancer. However, as immunotherapy is used to manipulate the patient’s own immune system, it can have effects on their microbiome. The microbiome can both affect the response to immunotherapy and itself be affected by immunotherapy, leading to harmful changes in the microbiome. Additionally, microbial-related therapies can be used in combination with immunotherapy to increase their efficacy. Understanding the interaction between immunotherapy and the microbiome is important for harnessing the full potential of immunotherapy.
This Collection invites preclinical and clinical research on immunotherapy and the microbiome.