Autophagy and anti-tumour immunity
- Submission status
- Open
- Submission deadline
Autophagy is an evolutionarily conserved intracellular degradative and recycling process for the elimination of damaged organelles, cellular debris, and is essential for cellular homeostasis and to promote cell survival. Autophagy plays paradoxical roles in tumorigenesis, depending on the stage of tumour development. Early on, it acts as a tumour suppressive mechanism by degrading damaged oxidative organelles to prevent the accumulation of oxygen radicals and oncogenic molecules, however in advanced stages, autophagy promotes the survival of tumour cells by reducing stress in the microenvironment, thus acting as a cell resistance mechanism. Autophagy has emerged as a cell resistance mechanism promoting tumour evasion from immune surveillance. Yet the role of autophagy on cancer immune escape remains to be elucidated. Targeting autophagy offers the possibility for new immunotherapeutic strategies to block immune escape.
This Collection invites work that sheds light on the mechanisms of autophagy in anti-tumour immunity, as well as articles highlighting the therapeutic potential of autophagy in tackling immunotherapy resistance.
Editors
-
Manjusha Dixit
Associate Professor, School of Biological Sciences, National Institute of Science Education and Research, Bhubaneswar, India.
-
Sufi Mary Thomas
Associate Professor, Department of Otolaryngology, Cancer Biology Program, University of Kansas Medical Center, USA
