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The role of epigenetic mechanisms, such as DNA or RNA methylation, histone modifications, nucleosome changes, and non-coding RNAs in cancer has gained increasing interest in recent studies. The reversible nature of epigenetic changes holds promise for the development of epigenetic therapeutic approaches and several of them have been approved for clinical use so far.
With this cross-journal Collection, the editors at Nature Communications, Communications Biology, Communications Medicine and Scientific Reports invite submissions covering the breadth of research carried out in the field of cancer epigenetics. We will highlight studies aiming at the improvement of our understanding of the epigenetic mechanisms underlying cancer initiation, progression, response to therapy, metastasis and tumour plasticity as well as findings that have the potential to be translated into the clinic.