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The endomembrane system is a key feature of eukaryotic cells. Many of the major protein families involved in this system are largely conserved across eukaryotic species, from protists to megafauna. However, key differences between lineages shed light on the evolutionary histories and diversification of endomembrane system pathways across the eukaryotic domain. These diverse proteins may help us better understand differences in cellular function, with implications for fields ranging from biomedicine to climate science.
This Collection invites original research on the pathways that coordinate the functions of the plasma membrane, Golgi apparatus, endoplasmic reticulum, and lysosome, with a special emphasis on the diversity and molecular evolution of the proteins that define them.