Hereditary cancer
- Submission status
- Closed
- Submission deadline
Although cancer can have many causes, it is almost invariably associated with genetic lesions that drive tumor formation or progression. In up to 10% of cancers, these genetic lesions are familial or inherited. Such cases are generally associated with an inherited mutation in one or more tumor suppressor genes, and many of these individuals will develop cancer at a younger age than the general population. Therefore, understanding the biology underlying these mutations is necessary to improve treatment and screening. These mutations can also occur sporadically in individuals without a family history; therefore, understanding the signaling pathways involved in these syndromes is of broader interest. Additionally, some inherited genetic lesions may increase the risk of multiple types of cancer; therefore, understanding the varying roles these mutations play in cancer progression and identifying affected organs are vital.
This Collection focuses on hereditary cancers, including cell signaling underlying hereditary cancers, identifying novel pathogenic variants associated with hereditary cancers, and genetic testing and screening methods for hereditary cancers.
Editors
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Hikmat Abdel-Razeq
King Hussein Cancer Center, Jordan
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Rodney J. Scott
University of Newcastle, Australia
