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Transplantation-associated thrombotic microangiopathy: twenty-two years later

Bone Marrow Transplantation volume 30, pages 709–715 (2002)Cite this article

Abstract

A syndrome of microangiopathic hemolytic anemia, renal dysfunction and neurological abnormalities was first noted in bone marrow transplant recipients 22 years ago. Now known as transplantation-associated thrombotic microangiopathy (TA-TMA) to distinguish it from other thrombotic microangiopathies, this disorder responds poorly to conventional treatments for thrombotic thrombocytopenic purpura. In this review, we discuss the incidence and risk factors for TA-TMA and describe a pathophysiologic model of the disorder based on results obtained from laboratory models of the thrombotic microangiopathies. We conclude by suggesting possible approaches to the early diagnosis and treatment of TA-TMA based on this model that may warrant testing in future clinical trials.

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  1. Department of Medical Oncology and Hematology, Allogeneic Bone Marrow Transplant Service, Princess Margaret Hospital/University Health Network, University of Toronto, Toronto, Ontario, Canada

    AS Daly, A Xenocostas & JH Lipton

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Daly, A., Xenocostas, A. & Lipton, J. Transplantation-associated thrombotic microangiopathy: twenty-two years later. Bone Marrow Transplant 30, 709–715 (2002). https://doi.org/10.1038/sj.bmt.1703710

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