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Infusion of lymphocytes obtained from a donor immunised with the paraprotein idiotype as a treatment in a relapsed myeloma

Bone Marrow Transplantation volume 25, pages 1105–1108 (2000)Cite this article

Abstract

A 48-year-old patient with IgA k multiple myeloma received a BMT from his HLA-matched sibling. After transplantation, the disease relapsed. Melphalan therapy followed by reinfusion of haemopoietic blood stem cells collected from the patient led to the improvement of the clinical status, although mixed chimerism and an elevated serum IgA persisted. Successful donor immunisation against an immunogenic preparation of the recipient monoclonal protein was performed before the infusion of donor T lymphocytes (DLI) into the patient. Ten weeks after the lymphocyte infusions, no monoclonal band was evidenced and donor complete chimerism was detected. The patient did not develop GVHD. Once complete remission was achieved, the idiotype vaccine was administered to the patient. Nineteen months after DLI, the patient remains in remission. Bone Marrow Transplantation (2000) 25, 1105–1108.

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Acknowledgements

The study was financed by grant No. 97/0963 from the FIS, Spain.

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Authors and Affiliations

  1. Department of Hematology, Clínica Puerta de Hierro, Universidad Autónoma de Madrid, Spain

    R Cabrera, M Briz, R Forés, L Barbolla, I Sanjuán, C Regidor, FJ Peñalver & MN Fernández

  2. Department of Immunology, Clínica Puerta de Hierro, Universidad Autónoma de Madrid, Spain

    F Díaz-Espada & Y Barrios

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  1. R Cabrera
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  2. F Díaz-Espada
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  3. Y Barrios
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  4. M Briz
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  5. R Forés
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  6. L Barbolla
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  7. I Sanjuán
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  8. C Regidor
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  9. FJ Peñalver
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  10. MN Fernández
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Cabrera, R., Díaz-Espada, F., Barrios, Y. et al. Infusion of lymphocytes obtained from a donor immunised with the paraprotein idiotype as a treatment in a relapsed myeloma. Bone Marrow Transplant 25, 1105–1108 (2000). https://doi.org/10.1038/sj.bmt.1702399

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  • DOI: https://doi.org/10.1038/sj.bmt.1702399

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