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Göz G. J Orofac Orthop 2013; 10.1007/s00056-013-0158-8

And the investigator states that although TMD may develop in a proportion of those treated with mandibular advancement devices, counterintuitively, those who present with '...TMD before treatment do not exhibit significantly worsened TMD during treatment...' and in some, the symptoms may even decrease. This latter conclusion contradicts the title of this paper. As background, 12% of those living in the US suffer from obstructive sleep apnoea (OSA). Positive airway pressure (PAP) is the gold standard although not tolerated by half of those patients who receive such treatment. In this retrospective study, consecutive patients (n = 167) with OSA (apnoea-hypopnoea index >5: 5–15, 10 second apnoeas/hr = mild) were treated with a mandibular advancement device. A posterior open bite developed in 6.6% of patients. Half the patients did not complete the study, usually because of muscle pain.