Key Points
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Aims to comprehensively review Resilon as a root filling material in practice.
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Highlights that current research although extensive it is of limited quality.
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Suggests that prospective clinical studies comparing Resilon to existing materials are required.
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Concludes that Resilon cannot yet be considered an evidence-based replacement to gutta-percha.
Abstract
Root canal treatment is achieved by chemo-mechanical debridement of the root canal system followed by filling. The filling material 'entombs' residual bacteria and acts as a barrier which prevents the entrance of oral microorganisms and reinfection of the root canal system through microleakage. However, filling with contemporary root filling materials such as gutta-percha offers limited long-term resistance to microorganisms; as a result other materials such as Resilon have been investigated as alternatives. The aim of this review was to analyse the literature to consider whether Resilon is a suitable root canal filling material. A MEDLINE and Cochrane library search including various keyword searches identified several papers which investigated or discussed Resilon or RealSeal/Epiphany. Analysis of the literature demonstrated that the bulk of the literature is in vitro in nature, based largely on leakage-type studies, and demonstrates a wide variety of methodologies with conflicting findings; as a result meaningful conclusions are difficult. Within the limit of these in vitro studies Resilon appears to perform adequately in comparison to gutta-percha, however, as a result of the questionable merit of such studies, it cannot presently be considered an evidence-based alternative to the current gold standard gutta-percha. It is imperative that before Resilon is considered as a replacement material, a better understanding of the physical properties of the resin sealer and the reality of the adhesive 'monoblock' are elucidated. The literature also demonstrates a paucity of quality long-term clinical outcome studies which will need to be addressed before firm conclusions can be reached.
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Introduction
The biological aim of endodontic treatment is to eliminate or prevent apical periodontitis.1 This is achieved by chemo-mechanical debridement of the root canal space followed by obturation. The role of a root canal filling material is to seal the disinfected canal apically, laterally and coronally. If the coronal seal fails the root canal filling should ideally prevent reinfection and the spread of microorganisms and their byproducts towards the tooth apex.2,3,4 In addition a root filling material should be easily introduced into the canal, dimensionally stable, biocompatible, bactericidal (or at least discourage bacterial growth), sterile, radiopaque, readily removed and should not stain tooth structure.5 Finally, the root canal filling material should strengthen the remaining root structure.6
Gutta-percha has been the obturation material of choice for many years. It has a proven track record, is considered the 'gold standard' and possesses many of the features of an ideal root filling material. However, it does not bond to tooth structure and its ability to prevent leakage has been questioned.7,8,9,10,11,12,13,14,15,16 In addition, it does not strengthen endodontically treated teeth6 and it is not possible to completely remove it during retreatment.17,18
In an attempt to address these shortcomings the use of materials which bond to the root canal dentine have been investigated; these include glass ionomers19 and resins.20 Several resin sealers such as AH-26/AH-plus (Dentsply Maillefer, Ballaigues, Switzerland), Endorez (Ultradent Products, South Jordan, Utah, USA) Realseal (Pentron Clinical Technologies, Wallingford, Connecticut, USA) and Epiphany (Sybron Dental Specialities, Orange, California, USA) have recently become available. The aim of these resin bonding systems is to allow for the adhesion of the obturation material, sealer and dentine to one another with the aim of creating a 'monoblock'; this forms a hermitic seal increasing resistance to fracture.6 A potential drawback of bonding to the tooth surface is the inability to remove the material effectively during retreatment.21
Resilon (Resilon Research, LLC, Madison, Connecticut, USA) is a thermoplastic synthetic polymer-based root canal obturation material that was introduced in 2004.22 It contains methacrylate resin, bioactive glass, barium sulphate and bismuth oxychloride.22,23 It is claimed that the handling characteristics are similar to gutta-percha, and therefore traditional obturation techniques can be used.22 The accompanying sealant Epiphany/RealSeal is a dual-curable resin based composite (RBC) sealer. The matrix is a mixture of Bisphenol A epoxy (Bis-GMA), urethane dimethacrylate (UDMA) and hydrophilic dysfunctional methacrylates, while the filler consists of calcium hydroxide, barium sulphate, barium glass and silica.23
A series of recent studies have claimed that Resilon has several characteristics which offer an improvement over gutta-percha.22,24,25 However, attention has tended to focus on the advantage or otherwise of the resin sealers over conventional sealers rather than the obturation system in comparison to gutta-percha.26 The aim of this review was to analyse the literature assessing Resilon in order to investigate firstly whether it is a suitable root canal filling material and also whether it is an evidence-based alternative material to gutta-percha.
Review
Search strategy
A MEDLINE and Cochrane library search up to May 2011 was conducted using various keyword combinations including the terms 'Resilon', 'Epiphany', 'RealSeal' and 'Resin sealer'. In addition, bibliographies of all relevant papers and previous review articles were hand-searched. Any relevant work published in the English language and presenting pertinent information related to Resilon was considered for inclusion in the review. The combinations of search terms produced a list of 205 publications from MEDLINE and other sources. Initially, these titles and abstracts were screened. Thereafter, full text analysis was performed of the potentially relevant publications. Publications from the same author discussing identical issues were identified and the more relevant publications were selected for this review. Finally the articles were allocated to several categories for analysis according to the ideal requirements of a root filling material.5
Fracture resistance/root strengthening
Endodontically treated teeth are considered more susceptible to fracture27 and a proposed advantage of adhesive obturation systems, such as Resilon, is to reduce this by creating a 'monoblock.'28 Advocates of the system claim that a mechanically homogenous unit is formed between the root dentine and the obturation material, reinforcing the root.6,22 However, the unpredictable nature of intra-radicular dentine bonding has led to uncertainty over the Resilon/Epiphany 'monoblock'.29 Successful bonding of Epiphany to dentine has been shown to be difficult to achieve in even simple root canal systems where gap formation was common at the interface between the sealer and root canal wall.29 The unpredictable bond between Epiphany and root canal dentine has been attributed to polymerisation shrinkage,30 incomplete sealer-polymerisation as a result of residual uncured monomer,31 or as a result of the complex mechanical and anatomical challenge of root canal bonding.32,33,34 Therefore, at present the clinical reality of a 'monoblock' is questionable.35,36,37
Early studies compared the fracture resistance of roots obturated with Resilon/Epiphany compared to gutta-percha and an epoxy resin sealer.6,24 It was concluded that the Resilon system increased fracture resistance. This was corroborated by a later study comparing resin-based obturation system to gutta-percha.25 Other studies have found the opposite when Resilon was used in immature roots; perhaps this is due contraction stress during polymerisation.38,39,40 Concerns have been raised about the strengthening effect of the Resilon/Epiphany system as the modulus of elasticity between dentine and Resilon differs;41,42 this is likely to lead to breakdown of the adhesive bond. Other studies have demonstrated that Resilon is not mechanically stiff enough to give mechanical support to dentine after root canal treatment.43,44,45,46
Sealing ability/leakage
Over the last five years a plethora of leakage studies comparing the sealability of Resilon and gutta-percha have been published; these studies form the bulk of the scientific research on Resilon. All of this literature is in vitro in nature comparing gutta-percha to Resilon/Epiphany and other sealers. Although the clinical relevance of these studies has been questioned47,48, their conclusions are worthy of discussion due to a paucity of clinical data on Resilon. Several studies suggest that Resilon reduces leakage compared to gutta-percha (Table 1);22,26,49,50,51,52,53,54,55,56,57,58,59,60,61,62 others suggest no difference (Table 2),36,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79 while some report increased leakage with Resilon compared to gutta-percha (Table 3).80,81,82,83,84,85,86,87,88,89,90 However, analysis of leakage studies must be carried out with caution as a 'superior' result has a different meaning depending on the technique employed. For example, in a dye penetration test a reduced line of colour adjacent to the root filling material suggests a 'superior' result, while in a bacterial leakage test a 'superior' result occurs when bacteria reach the lower collection chamber later.
It is not clear what accounts for this variability, however, it may be due to a lack of standardisation and reliability of leakage studies, which hinders comparison.91 Other possible causes of experimental variation include unpredictable setting of resin materials in moist canals,92 chelating agents affecting the bond quality,93 certain irrigants affecting polymerisation94,95,96 or the type of curing light affecting polymerisation shrinkage and subsequent leakage.97 All these in vitro leakage studies are evaluated over a number of days or weeks and it has been suggested that this may give a false perspective of the behaviour of resin sealers as they may degrade88 or hydrolysis with time.35,98 Therefore, before any meaningful conclusions can be made long-term evaluations and clinical studies are necessary.
In one animal leakage study Resilon/Epiphany was compared to gutta-percha/AH-26 sealer and the resolution of induced apical periodontitis monitored.26 The study was carried out over six months on seven Beagle dogs. It was concluded that there was a comparative reduction in apical periodontitis compared to gutta-percha; it must be stressed however that the authors had a financial interest in the Resilon system.
Biocompatibility
Several in vitro studies have investigated the biocompatability of Resilon without sealer and reported it to compare favourably to gutta-percha99,100,101 This has been corroborated in an animal study.102 Other studies have compared Resilon to gutta-percha and concluded that Resilon was more biocompatible,103 however, another demonstrated the opposite.104 It was suggested that a reason for Resilon's potential cytotoxicity may be due to the biodegradability of Resilon by enzymes and alkaline hydrolysis, which would expose the more toxic polymer matrix.36,98
Epiphany sealer has been shown to be cytotoxic when compared to zinc oxide eugenol and epoxy-resin based sealers100,105,106,107,108,109,110 with one study suggesting that it became more cytotoxic with increased exposure time.111 However, it has also been demonstrated that although Epiphany was cytotoxic it did not effect the viability of human leucocytes.112 The reported cytotoxicity may be due to the leakage of uncured monomer from the oxygen inhibition layer,100,101,113,114 or due to the degradation of the sealer in an aqueous environment.115,116,117 The Bis-GMA and UDMA contained within the Epiphany bonding agent are another potential source of cytotoxicity.99,101,105,118 However, several in vivo studies have shown the biocompatibility of Epiphany to be acceptable.119,120,121,122,123,124
Physical properties
Setting times
Resilon's manufacturers claim that an immediate coronal seal can be produced by light curing for 40 seconds, while the remaining sealer sets in 25 minutes (RealSeal/Epiphany instructions, SybronEndo 2010). However, the reality of this has been questioned. It has been found that in anaerobic conditions, it will set in 30 minutes, but in aerobic conditions it can take up to three weeks, suggesting that Resilon will not completely set in the periradicular tissues should it be extruded.113
Radiopaque
Resilon/Epiphany has demonstrated acceptable radiopacity, exceeding the minimal radiopacity equivalent of 3 mm of aluminum, as recommended by the American National Standards Institute (ANSI) and the American Dental Association (ADA)125,126,127 (Figs 1a and 1d).
Staining
Resilon has the potential to cause tooth staining as it is susceptible to enzymatic and alkaline hydrolysis.36,98 This biodegradation may result in the leaching of dyes from the material. The formation of a precipitate and associated colour change has also been noted when Resilon is disinfected with 2% chlorohexidine.128 However, a one-year clinical study reported no staining associated with Resilon.129
Bacteriocidal/sterile
Resilon and Epiphany, when investigated individually and in combination, have demonstrated no significant antibacterial or antifungal effect.130,131,132,133,134 One study concluded that Epiphany may actually enhance bacterial growth135 and another that Enterococcus faecalis was resistant to Epiphany.133 Interestingly, in the latter study it was demonstrated that the Epiphany primer inhibited microbial growth using an agar diffusion method; however, this is unlikely to be clinically relevant.133
Removal of Resilon
An ideal requirement of a root canal filling material is that it should be readily retrievable to facilitate post-space preparation or retreatment. Although gutta-percha is considered relatively easy to remove it has been found that regardless of technique employed, complete removal of gutta-percha is not possible during retreatment.18,17,136 An advantage of Resilon is that it can be removed in a similar manner to gutta-percha (Table 4).137,138,139,140,141,142,143,144,145,146,147,148,149,150 A series of studies have compared the removal of Resilon to gutta-percha with the time taken for removal and residual material remaining the main variables investigated. Most studies have concluded that Resilon is readily removable using a variety of techniques. As with the sealability studies the results have been contradictory with some studies demonstrating the amount of residual debris to be less than that of gutta-percha root fillings,137,138,139,140,142 while others have found the opposite.141,145,148 The variation between these studies maybe attributable to Resilon/Epiphany not completely setting before retreatment and therefore being easier to remove,113,133 or that the canals were retreated to two sizes larger than the apical size before filling which would enhance the efficacy of retreatment.151,152,153 Ezzie and co-workers137 found that Resilon left less residual debris in the apical third of the root canal; this may be due to the fact that effective removal of the smear layer and subsequent bonding is difficult to achieve in this area.154,155 The vast majority of studies have compared Resilon/Epihany to gutta-percha and epoxy resin cement, however, this may prevent accurate extrapolation to other gutta-percha sealers as epoxy resins are associated with a higher level of residual debris than other cements.156
Chloroform has been recommended by the manufacturers as an aid in removal of Resilon (RealSeal/Epiphany instructions, SybronEndo 2010). However, resin sealers are not dissolved by chloroform and it has an adverse effect on bond strength of Resilon/Epiphany when reobturating.157,158
Clinical outcome studies
Randomised prospective clinical outcome studies comparing two different treatments are the gold standard in medical research. These studies are uncommon in endodontics and those published are often of low quality.159 To date only one clinical study has compared Resilon/Epiphany to gutta-percha/Kerr's sealer and it concluded that the outcome for both materials was not statistically different.160 However, this was a retrospective study with follow-up ranging from one month to two years; in addition there was only a limited number in each group. Other case-series studies have reported only on the outcome of Resilon/Epiphany obturated teeth without comparing to gutta-percha.129,161 In one retrospective study post-treatment radiographs were examined after one year and it was concluded that Resilon healing rates were similar to that of gutta-percha obturated canals.161 However, the review period was short, the numbers of teeth relatively small and there was no clinical examination. The short-term clinical effectiveness of Resilon/Epiphany was corroborated in a prospective study with both clinical and radiographic assessment being used to evaluate outcome.129 This study was preliminary in nature with only a small number of teeth treated and reviewed after one year.
Conclusions
Root canal filling is a key step in non-surgical endodontic treatment. The majority of recent studies have focused on the relative ability of Resilon to resist leakage; however, the results have been largely inconclusive with a group of studies suggesting Resilon is superior to gutta-percha and another group the opposite. The heterogeneity of methods employed within these studies makes comparison difficult and the clinical relevance of these in vitro studies is dubious. What can be concluded, however, is that although there is evidence to suggest that Resilon performs better and indeed worse than gutta-percha in leakage studies, it is difficult to extrapolate meaningful clinical conclusions from this literature. Perhaps a more relevant way of assessing the efficacy of Resilon would be to assess outcome in vivo; unfortunately these studies are time consuming and rare within endodontics. The literature suggests that Resilon is not stiff enough to strengthen residual root structure; however, more information is required on the nature of the adhesive bond between sealer and root dentine and whether the reported in vitro 'monoblock' is translated clinically. The predictability of bonding in the apical reaches of the root canal remains to be elucidated as the use of resin sealers and bonding within the root canal is relatively new. The techniques and materials are likely to evolve over the next few years; this may lead to an improvement in both our knowledge and results. In terms of biocompatibility and physical properties Resilon appears to perform well comparing favourably to gutta-percha, although there are concerns regarding the cytotoxicity of the Epiphany sealer. Definitive conclusions cannot be reached as yet with regard to ease of removal compared to gutta-percha, however, it appears to compare favourably to gutta-percha using a variety of removal techniques. There is an absence of randomised clinical outcome studies comparing gutta-percha to Resilon and until these are available it is impossible to adequately assess Resilon as a replacement for gutta-percha which has an established research track record over many years. These outcome studies, perhaps through large multicentred trials, should form the focus of attention rather than further in vitro leakage studies. The issue of whether Resilon is a suitable material is impossible to adequately assess at present and only time will tell if it proves an evidence-based alternative or replacement for gutta-percha.
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Shanahan, D., Duncan, H. Root canal filling using Resilon: a review. Br Dent J 211, 81–88 (2011). https://doi.org/10.1038/sj.bdj.2011.573
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DOI: https://doi.org/10.1038/sj.bdj.2011.573