Preserving hemostasis while preventing pathological thrombosis has been a central goal in drug development. A new way to restore hemostasis is suggested by the finding that glycoprotein V is cleaved by thrombin on activated platelets, negatively regulating clotting at sites of vascular injury.
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Knauss, E.A., Nieman, M.T. Glycoprotein V exerts local control of fibrin. Nat Cardiovasc Res 2, 335–336 (2023). https://doi.org/10.1038/s44161-023-00261-7
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DOI: https://doi.org/10.1038/s44161-023-00261-7
