Thrombosis

Definition

Thrombosis is the formation of a blood clot in any part of the cardiovascular system – that is, within a blood vessel or the heart.

Latest Research and Reviews

  • Research | | open

    Numerous genetic variants, including those located in the non-coding regions of the genome, are known to be associated with blood cells traits. Here, Frontini and colleagues investigate their potential regulatory functions using epigenomic data and promoter long-range interactions.

    • Romina Petersen
    • , John J. Lambourne
    • , Biola M. Javierre
    • , Luigi Grassi
    • , Roman Kreuzhuber
    • , Dace Ruklisa
    • , Isabel M. Rosa
    • , Ana R. Tomé
    • , Heather Elding
    • , Johanna P. van Geffen
    • , Tao Jiang
    • , Samantha Farrow
    • , Jonathan Cairns
    • , Abeer M. Al-Subaie
    • , Sofie Ashford
    • , Antony Attwood
    • , Joana Batista
    • , Heleen Bouman
    • , Frances Burden
    • , Fizzah A. Choudry
    • , Laura Clarke
    • , Paul Flicek
    • , Stephen F. Garner
    • , Matthias Haimel
    • , Carly Kempster
    • , Vasileios Ladopoulos
    • , An-Sofie Lenaerts
    • , Paulina M. Materek
    • , Harriet McKinney
    • , Stuart Meacham
    • , Daniel Mead
    • , Magdolna Nagy
    • , Christopher J. Penkett
    • , Augusto Rendon
    • , Denis Seyres
    • , Benjamin Sun
    • , Salih Tuna
    • , Marie-Elise van der Weide
    • , Steven W. Wingett
    • , Joost H. Martens
    • , Oliver Stegle
    • , Sylvia Richardson
    • , Ludovic Vallier
    • , David J. Roberts
    • , Kathleen Freson
    • , Lorenz Wernisch
    • , Hendrik G. Stunnenberg
    • , John Danesh
    • , Peter Fraser
    • , Nicole Soranzo
    • , Adam S. Butterworth
    • , Johan W. Heemskerk
    • , Ernest Turro
    • , Mikhail Spivakov
    • , Willem H. Ouwehand
    • , William J. Astle
    • , Kate Downes
    • , Myrto Kostadima
    •  & Mattia Frontini
  • Research | | open

    The binding of the leukocyte integrin Mac1 to the platelet receptor GPIbα is important for the physiological response to tissue injury. Here the authors show that this interaction also regulates thrombosis, without influencing bleeding time, which may provide clues for the development of new anti-thrombotic drugs.

    • Yunmei Wang
    • , Huiyun Gao
    • , Can Shi
    • , Paul W. Erhardt
    • , Alexander Pavlovsky
    • , Dmitry A. Soloviev
    • , Kamila Bledzka
    • , Valentin Ustinov
    • , Liang Zhu
    • , Jun Qin
    • , Adam D. Munday
    • , Jose Lopez
    • , Edward Plow
    •  & Daniel I. Simon
  • Reviews |

    Anaemia, thrombosis and smooth muscle dystonias are manifestations of paroxysmal nocturnal haemoglobinuria, a rare but potentially life-threatening haematological disorder. Inhibition of complement activation is the treatment of choice; stem cell transplantation is recommended for patients who also develop severe bone marrow failure.

    • Anita Hill
    • , Amy E. DeZern
    • , Taroh Kinoshita
    •  & Robert A. Brodsky