Thrombosis

Definition

Thrombosis is the formation of a blood clot in any part of the cardiovascular system – that is, within a blood vessel or the heart.

Latest Research and Reviews

  • Research | | open

    A major drawback in the clinical use of the oral anticoagulants that directly inhibit factor Xa in order to prevent blood clot formation is the potential for life threatening bleeding events. Here the authors describe factor Xa variants that are refractory to inhibition by these anticoagulants and could serve as rescue agents in treated patients.

    • Daniël Verhoef
    • , Koen M. Visscher
    • , C. Ruben Vosmeer
    • , Ka Lei Cheung
    • , Pieter H. Reitsma
    • , Daan P. Geerke
    •  & Mettine H. A. Bos
  • Reviews |

    The left atrial appendage is known to be a source of thromboemboli in patients with nonvalvular atrial fibrillation, and the interventional or surgical occlusion or exclusion of this anatomical structure is an alternative approach to anticoagulation therapy for the prevention of stroke. In this Review, Caliskan et al. discuss the various methods for occlusion of the left atrial appendage, and provide an overview of the clinical studies investigating these techniques.

    • Etem Caliskan
    • , James L. Cox
    • , David R. Holmes Jr
    • , Bernhard Meier
    • , Dhanunjaya R. Lakkireddy
    • , Volkmar Falk
    • , Sacha P. Salzberg
    •  & Maximilian Y. Emmert
  • Research | | open

    Numerous genetic variants, including those located in the non-coding regions of the genome, are known to be associated with blood cells traits. Here, Frontini and colleagues investigate their potential regulatory functions using epigenomic data and promoter long-range interactions.

    • Romina Petersen
    • , John J. Lambourne
    • , Biola M. Javierre
    • , Luigi Grassi
    • , Roman Kreuzhuber
    • , Dace Ruklisa
    • , Isabel M. Rosa
    • , Ana R. Tomé
    • , Heather Elding
    • , Johanna P. van Geffen
    • , Tao Jiang
    • , Samantha Farrow
    • , Jonathan Cairns
    • , Abeer M. Al-Subaie
    • , Sofie Ashford
    • , Antony Attwood
    • , Joana Batista
    • , Heleen Bouman
    • , Frances Burden
    • , Fizzah A. Choudry
    • , Laura Clarke
    • , Paul Flicek
    • , Stephen F. Garner
    • , Matthias Haimel
    • , Carly Kempster
    • , Vasileios Ladopoulos
    • , An-Sofie Lenaerts
    • , Paulina M. Materek
    • , Harriet McKinney
    • , Stuart Meacham
    • , Daniel Mead
    • , Magdolna Nagy
    • , Christopher J. Penkett
    • , Augusto Rendon
    • , Denis Seyres
    • , Benjamin Sun
    • , Salih Tuna
    • , Marie-Elise van der Weide
    • , Steven W. Wingett
    • , Joost H. Martens
    • , Oliver Stegle
    • , Sylvia Richardson
    • , Ludovic Vallier
    • , David J. Roberts
    • , Kathleen Freson
    • , Lorenz Wernisch
    • , Hendrik G. Stunnenberg
    • , John Danesh
    • , Peter Fraser
    • , Nicole Soranzo
    • , Adam S. Butterworth
    • , Johan W. Heemskerk
    • , Ernest Turro
    • , Mikhail Spivakov
    • , Willem H. Ouwehand
    • , William J. Astle
    • , Kate Downes
    • , Myrto Kostadima
    •  & Mattia Frontini

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