An engineered ‘carbene transferase’ is shown to convert both Z and E isomers of silyl enol ethers in a stereoconvergent manner, yielding chiral α-branched ketones with high efficiency and excellent selectivity. This biocatalyst offers an efficient and high-yield method to functionalize these alkene mixtures.
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References
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This is a summary of: Mao, R. et al. Biocatalytic, stereoconvergent alkylation of (Z/E)-trisubstituted silyl enol ethers. Nat. Synth. https://doi.org/10.1038/s44160-023-00431-2 (2023).
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An engineered enzyme that enables the stereoconvergent alkylation of alkene mixtures. Nat. Synth 3, 160–161 (2024). https://doi.org/10.1038/s44160-023-00446-9
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DOI: https://doi.org/10.1038/s44160-023-00446-9
