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Synthetic methodology

Two nucleophiles take turns

Palladium-catalysed dicarbonylation using two different nucleophiles enables the selective synthesis of unsymmetrical diamides and amido esters in a single step.

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Fig. 1: Pd-catalysed dicarbonylative formation of unsymmetric diamide or amido esters.

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Correspondence to Bruce A. Arndtsen.

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Zgheib, J., Arndtsen, B.A. Two nucleophiles take turns. Nat. Synth 3, 148–149 (2024). https://doi.org/10.1038/s44160-023-00393-5

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