By conducting single-cell meta-analyses of inflammatory bowel disease, we identify rare or less-characterized cell subtypes linked to GWAS risk genes and therapeutic targets and dissect the commonalities and differences between ulcerative colitis and Crohn’s disease. Consequently, we present an interactive and user-friendly platform for the research community.
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References
Chang, J. T. Pathophysiology of inflammatory bowel diseases. N. Engl. J. Med. 383, 2652–2664 (2020). This review article presents the current understanding of the pathogenesis of IBD.
Martin, J. C. et al. Single-cell analysis of Crohn’s disease lesions identifies a pathogenic cellular module associated with resistance to anti-TNF therapy. Cell 178, 1493–1508 (2021). This paper reports a pathogenic cellular module in patients with CD.
Smillie, C. S. et al. Intra-and inter-cellular rewiring of the human colon during ulcerative colitis. Cell 178, 714–730 (2019). This paper reports cell types relevant to UC and maps risk variants to these cell types and pathways.
Huang, H. et al. Fine-mapping inflammatory bowel disease loci to single-variant resolution. Nature 547, 173–178 (2017). This paper reports genetic variants and associated genes in IBD.
Zhang, L. et al. Single-cell analyses inform mechanisms of myeloid-targeted therapies in colon cancer. Cell 181, 442–459 (2020). This paper characterizes myeloid cells in colorectal cancer and their differences between colorectal cancer and UC.
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This is a summary of: Nie, H. et al. Single-cell meta-analysis of inflammatory bowel disease with scIBD. Nat. Comput. Sci. https://doi.org/10.1038/s43588-023-00464-9 (2023).
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A single-cell transcriptomic meta-analysis platform for inflammatory bowel disease. Nat Comput Sci 3, 482–483 (2023). https://doi.org/10.1038/s43588-023-00474-7
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DOI: https://doi.org/10.1038/s43588-023-00474-7
