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Progeria

Missing checkpoints in premature aging

Nature Aging volume 3, pages 146–147 (2023)Cite this article

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Zhang and colleagues demonstrate how the premature aging phenotypes in progeria involve a mitotic spindle-assembly-checkpoint protein, BUBR1. BUBR1 is misanchored to the nuclear membrane by progerin and its mRNA is destabilized in progeria, preventing it from functioning properly.

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Fig. 1: A dual role of UPCP in rescuing BUBR1-induced phenotypes in progeria.

References

  1. Eriksson, M. et al. Nature 423, 293–298 (2003).

    Article  CAS  PubMed  Google Scholar 

  2. Koblan, L. W. et al. Nature 589, 608–614 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Erdos, M. R. et al. Nat. Med. 27, 536–545 (2021).

    Article  CAS  PubMed  Google Scholar 

  4. Chen, C.-Y. et al. Cell 149, 565–577 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Lee, S. J. et al. J. Clin. Invest. 126, 3879–3893 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Zhang, N. et al. Nat. Aging https://doi.org/10.1038/s43587-023-00361-w (2023).

    Article  PubMed  Google Scholar 

  7. Fang, G. Mol. Biol. Cell 13, 755–766 (2002).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Baker, D. J. et al. Nat. Cell Biol. 15, 96–102 (2013).

    Article  CAS  PubMed  Google Scholar 

  9. Kapanidou, M., Lee, S. & Bolanos-Garcia, V. M. Trends Mol. Med. 21, 364–372 (2015).

    Article  CAS  PubMed  Google Scholar 

  10. Baker, D. J. et al. Nat. Genet. 36, 744–749 (2004).

    Article  CAS  PubMed  Google Scholar 

  11. Cao, K., Capell, B. C., Erdos, M. R., Djabali, K. & Collins, F. S. Proc. Natl Acad. Sci. 104, 4949–4954 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Dechat, T. et al. Proc. Natl Acad. Sci. 104, 4955–4960 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Kang, S. et al. Commun. Biol. 4, 5 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Cao, K. et al. J. Clin. Invest. 121, 2833–2844 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

The authors are supported by NIH/NHLBI R01HL138252 (K.C.) and a seed grant from Brain and Behaviour Institute (BBI) at the University of Maryland College Park (H.X.).

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  1. Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD, USA

    Huijing Xue & Kan Cao

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  1. Huijing Xue
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  2. Kan Cao
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Correspondence to Kan Cao.

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The authors declare no competing interests.

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Xue, H., Cao, K. Missing checkpoints in premature aging. Nat Aging 3, 146–147 (2023). https://doi.org/10.1038/s43587-022-00351-4

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