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Cancer metabolism

Metabolic symbiosis in pancreatic cancer

Nature Cancer volume 3, pages 1277–1278 (2022)Cite this article

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Pancreatic ductal carcinoma exists within a heterogenous and complex microenvironment that imposes austere conditions with limited nutrient availability. Clonally separable neoplastic cell populations are now shown to segregate into two distinct metabolic configurations, facilitating symbiotic intratumoral crosstalk to support survival and growth.

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Fig. 1: Metabolic symbiosis in pancreatic cancer.

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Authors and Affiliations

  1. MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK

    Dylan Gerard Ryan

  2. CECAD Research Centre, University of Cologne, Cologne, Germany

    Christian Frezza

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  1. Dylan Gerard Ryan
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  2. Christian Frezza
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Correspondence to Christian Frezza.

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The authors declare no competing interests.

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Ryan, D.G., Frezza, C. Metabolic symbiosis in pancreatic cancer. Nat Cancer 3, 1277–1278 (2022). https://doi.org/10.1038/s43018-022-00454-2

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