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TUMOR MICROENVIRONMENT

NUFIP1+ stroma keeps PDAC fed

Nature Cancer volume 3, pages 909–910 (2022)Cite this article

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How pancreatic ductal adenocarcinoma persists despite limited nutrients within the tumor microenvironment warrants further investigation. A study now identifies a metabolic mechanism wherein NUFIP1 induces release of nucleosides from cancer-associated fibroblasts, leading to activation of MYC-dependent glucose consumption and tumor growth.

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Fig. 1: CAF-derived nucleosides mitigate PDAC tumor growth within the nutrient-low PDAC TME via NUFIP1.

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Authors and Affiliations

  1. Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR, USA

    Holly Sandborg & Mara H. Sherman

  2. Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA

    Mara H. Sherman

Authors
  1. Holly Sandborg
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  2. Mara H. Sherman
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Correspondence to Mara H. Sherman.

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The authors declare no competing interests.

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Sandborg, H., Sherman, M.H. NUFIP1+ stroma keeps PDAC fed. Nat Cancer 3, 909–910 (2022). https://doi.org/10.1038/s43018-022-00421-x

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