Calcium sensing receptor (CaSR) and peptide transporter 1 (PepT1) have been implicated in protein sensing in the gut, although the mechanisms are poorly understood. We find that, in the small intestine, CasR and PepT1 are necessary for protein sensing to regulate gut peptide release, feeding and glucose tolerance in rats in vivo.
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References
Duca, F. A. et al. The metabolic impact of small intestinal nutrient sensing. Nat. Commun. 12, 903 (2021). A review that highlights the impact of small intestinal nutrient sensing mechanisms on gut peptide, feeding and glucose regulation.
Diakogiannaki, E. et al. Oligopeptides stimulate glucagon-like peptide 1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor. Diabetologia 56, 2688–2696 (2013). This paper reports that PepT1 and CaSR mediate protein sensing to increase glucagon-like peptide 1 secretion.
Modvig, I. M. et al. Peptone-mediated glucagon-like peptide 1 secretion depends on intestinal absorption and activation of basolaterally located calcium-sensing receptors. Physiol. Rep. 7, e14056 (2019). This paper reports that PepT1 and basolateral CaSR act dependently for glucagon-like peptide 1 secretion.
Igarashi, A. et al. Acute oral calcium suppresses food intake through enhanced peptide-YY secretion mediated by the calcium-sensing receptor in rats. J. Nutr. 151, 1320–1328 (2021). This paper reports that CaSR agonist, cinacalcet, lowers food intake in rats.
Muramatsu, M. et al. Activation of the gut calcium-sensing receptor by peptide agonists reduces rapid elevation of plasma glucose in response to oral glucose loads in rats. Am J Physiol. Gastrointest. Liver Physiol. 306, G1099–107 (2014). This paper reports that CaSR agonist, cinacalcet, lowers glucose levels in rats.
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This is a summary of: Li, R. J. W. et al. Small intestinal CaSR-dependent and CaSR-independent protein sensing regulates feeding and glucose tolerance in rats. Nat. Metab. https://doi.org/10.1038/s42255-023-00942-4 (2024).
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Small intestinal protein sensing pathways regulate food intake and glucose homeostasis. Nat Metab 6, 14–15 (2024). https://doi.org/10.1038/s42255-023-00947-z
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DOI: https://doi.org/10.1038/s42255-023-00947-z
