Oncometabolites are pro-tumourigenic metabolites that can determine tumour aggressiveness. This study found that methylmalonic acid is upregulated in breast lung metastasis and metastatic cancer cells. Methylmalonic acid alters the gene expression profile to induce a pro-metastatic phenotype in breast and lung cancer cells.
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Kay, E.J., Zanivan, S. Methylmalonic acid: an age-related metabolite that drives tumour aggressiveness. Nat Metab 4, 412–413 (2022). https://doi.org/10.1038/s42255-022-00540-w
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DOI: https://doi.org/10.1038/s42255-022-00540-w
