Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

EXERCISE

Run to survive—how preoperative exercise could prevent major surgical complications

Nature Metabolism volume 3, pages 732–734 (2021)Cite this article

Subjects

Preoperative exercise and a high fitness level can confer protection against postoperative stress. In this issue, Zhang et al. report that a short 4-week exercise regimen before liver surgery induces beneficial immunometabolic adaptations in Kupffer cells. Notably, the exercise-induced expression of immune-responsive gene 1 (Irg1) drives Kupffer cells toward an anti-inflammatory phenotype with decreased markers of postoperative hepatic ischaemia–reperfusion injury.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Preoperative exercise protects against hepatic inflammation by inducing beneficial immunometabolic alterations in Kupffer cells.

References

  1. Richardson, K., Levett, D. Z. H., Jack, S. & Grocott, M. P. W. Br. J. Anaesth. 119, i34–i43 (2017).

    Article  CAS  Google Scholar 

  2. Assouline, B. et al. Ann. Am. Thorac. Soc. 18, 678–688 (2021).

    Article  Google Scholar 

  3. Zhang, H. et al. Nat. Metab. https://doi.org/10.1038/s42255-021-00402-x (2021).

  4. Ahmed, O., Robinson, M.W. & O’Farrelly, C. Cell. Mol. Immunol. https://doi.org/10.1038/s41423-021-00639-2 (2021).

  5. Cordes, T. et al. J. Biol. Chem. 291, 14274–14284 (2016).

    Article  CAS  Google Scholar 

  6. Cordes, T. et al. Mol. Metab. 32, 122–135 (2020).

    Article  CAS  Google Scholar 

  7. Goh, J. et al. Transl. Med. Commun. 5, 4 (2020).

    Article  Google Scholar 

  8. He, W., Heinz, A., Jahn, D. & Hiller, K. Curr. Opin. Biotechnol. 68, 231–239 (2021).

    Article  CAS  Google Scholar 

  9. Yi, Z. et al. Hepatology 72, 1394–1411 (2020).

    Article  CAS  Google Scholar 

  10. Lobo, D. N. et al. Clin. Nutr. 39, 3211–3227 (2020).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Technische Universiät Braunschweig, Department of Bioinfomatics and Biochemistry, Braunschweig Integrated Center of Systems Biology (BRICS), Braunschweig, Germany

    Alexander Heinz & Karsten Hiller

  2. Computational Biology of Infection Research, Helmholtz Centre for Infection Research, Braunschweig, Germany

    Karsten Hiller

Authors
  1. Alexander Heinz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Karsten Hiller
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Karsten Hiller.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Heinz, A., Hiller, K. Run to survive—how preoperative exercise could prevent major surgical complications. Nat Metab 3, 732–734 (2021). https://doi.org/10.1038/s42255-021-00403-w

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s42255-021-00403-w

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing