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Pancreatic islet secretion: gabbling via GABA

Nature Metabolism volume 1, pages 1032–1033 (2019)Cite this article

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A new study by Menegaz et al. in this issue of Nature Metabolism addresses fundamental questions on the acute regulation and role of GABA secretion in pancreatic islets.

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Fig. 1: Role of β-cell-derived GABA in the coordination of glucagon and insulin secretion in health and in type 2 diabetes.

References

  1. Rutter, G. A., Pullen, T. J., Hodson, D. J. & Martinez-Sanchez, A. Biochem. J. 466, 202–218 (2015).

    Article  Google Scholar 

  2. Gromada, J., Chabosseau, P. & Rutter, G. A. Nat. Rev. Endocrinol. 14, 694–704 (2018).

    Article  CAS  Google Scholar 

  3. Braun, M. et al. Diabetes 59, 1694–1701 (2010).

    Article  CAS  Google Scholar 

  4. Rorsman, P. et al. Proc. Natl. Acad. Sci. USA 86, 4505–4509 (1989).

    Article  CAS  Google Scholar 

  5. Bailey, S. J., Ravier, M. A. & Rutter, G. A. Diabetes 56, 320–327 (2007).

    Article  CAS  Google Scholar 

  6. Smismans, A., Schuit, F. & Pipeleers, D. Diabetologia 40, 1411–1415 (1997).

    Article  CAS  Google Scholar 

  7. Menegaz, D. et al. Nat. Metab. https://doi.org/10.1038/s42255-019-0135-7 (2019).

    Article  Google Scholar 

  8. Best, L. & Yates, A. P. Islets 2, 303–307 (2010).

    Article  Google Scholar 

  9. Johnston, N. R. et al. Cell Metab. 24, 389–401 (2016).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Section of Cell Biology and Functional Genomics, Department of Metabolism, Reproduction and Digestion, Faculty of Medicine, Hammersmith Hospital, Imperial College London, London, UK

    Guy A. Rutter

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  1. Guy A. Rutter
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Correspondence to Guy A. Rutter.

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The author declares no competing interests.

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Rutter, G.A. Pancreatic islet secretion: gabbling via GABA. Nat Metab 1, 1032–1033 (2019). https://doi.org/10.1038/s42255-019-0142-8

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