Hydrogenases are very powerful biocatalysts for dihydrogen cleavage. Now, X-ray crystallography shows how [Fe]-hydrogenase requires ligand exchanges at the metal centre and significant molecular motions to open and close its active site to effectively transfer a hydride to an electrophilic organic substrate.
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Nicolet, Y. How [Fe]-hydrogenase metabolizes dihydrogen. Nat Catal 2, 481–482 (2019). https://doi.org/10.1038/s41929-019-0296-5
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DOI: https://doi.org/10.1038/s41929-019-0296-5