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BIOCATALYSIS

Enzymes working in reverse

Nature Catalysis volume 1, pages 172–173 (2018)Cite this article

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Lyases are enzymes that catalyse the breaking of chemical bonds. Now, reversing this reaction towards carbon–nitrogen bond formation allows for the synthesis of various chiral aminocarboxylic acids such as the potential antibiotic co-drug aspergillomarasmine A.

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Fig. 1: EDDS-lyase-driven C–N bond breaking and formation.

References

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  1. Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA

    Romas J. Kazlauskas

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  1. Romas J. Kazlauskas
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Correspondence to Romas J. Kazlauskas.

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Kazlauskas, R.J. Enzymes working in reverse. Nat Catal 1, 172–173 (2018). https://doi.org/10.1038/s41929-018-0041-5

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