The microtubule motor dynein is regulated by lissencephaly-1 (Lis1) at several points during its complex activation process. Two papers reveal the molecular mechanism for two steps: the beginning, when Lis1 acts as a wedge to disrupt dynein’s autoinhibited conformation; and the end, when microtubule binding ejects Lis1 from the motor.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Markus, S. M., Marzo, M. G. & McKenney, R. J. Elife 9, e59737 (2020).
Karasmanis, E. P. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-023-01069-6 (2023).
Ton, W. D. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-023-01010-x (2023).
Zhang, K. et al. Cell 169, 1303–1314 (2017).
Marzo, M. G., Griswold, J. M. & Markus, S. M. Nat. Cell Biol. 22, 559–569 (2020).
Htet, Z. M. et al. Nat. Cell Biol. 22, 518–525 (2020).
Gillies, J. P. et al. Elife 11, e71229 (2022).
Elshenawy, M. M. et al. Nat Cell Biol 22, 570–578 (2020).
Gutierrez, P. A., Ackermann, B. E., Vershinin, M. & McKenney, R. J. J. Biol. Chem. 292, 12245–12255 (2017).
Jha, R., Roostalu, J., Cade, N. I., Trokter, M. & Surrey, T. EMBO J. 36, 3387–3404 (2017).
Baumbach, J. et al. Elife 6, e21768 (2017).
Kusakci, E., Htet, Z. M., Gillies, J. P., Reck-Peterson, S. L. & Yildiz, A. Preprint at bioRxiv https://doi.org/10.1101/2022.06.02.494578 (2022).
DeSantis, M. E. et al. Cell 170, 1197–1208.e12 (2017).
Reimer, J. M., Desantis, M. E., Reck-Peterson, S. L. & Leschziner, A. E. Elife 12, e84302 (2023).
Toropova, K. et al. Elife 3, e03372 (2014).
Acknowledgements
I thank K. Singh for comments during revision. C.K.L. receives funding from a Wellcome Trust Career Development Award (225292/Z/22/Z).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Lau, C.K. New pieces for the Lis1–dynein puzzle. Nat Struct Mol Biol 30, 1244–1246 (2023). https://doi.org/10.1038/s41594-023-01084-7
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41594-023-01084-7