The class II phosphatidylinositol 3-kinases (PI3Ks) serve important roles in diverse cellular processes. The lab of Volker Haucke has now determined high-resolution structures of mouse PI3KC2α in both active and inactive conformations, elucidating the autoregulatory mechanism of class II PI3K activation.
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References
Bilanges, B., Posor, Y. & Vanhaesebroeck, B. Nat. Rev. Mol. Cell Biol. 20, 515–534 (2019).
Thorpe, L. M., Yuzugullu, H. & Zhao, J. J. Nat. Rev. Cancer 15, 7–24 (2015).
Fruman, D. A. et al. Cell 170, 605–635 (2017).
Vadas, O., Burke, J. E., Zhang, X., Berndt, A. & Williams, R. L. Sci. Signal. 4, re2 (2011).
Rostislavleva, K. et al. Science 350, aac7365 (2015).
Koch, P. A., Dornan, G. L., Hessenberger, M. & Haucke, V. FEBS J. 288, 7025–7042 (2021).
Burke, J. E. Mol. Cell 71, 653–673 (2018).
Young, L. N., Goerdeler, F. & Hurley, J. H. Proc. Natl Acad. Sci. USA 116, 21508–21513 (2019).
Ma, M. et al. Cell Res. 27, 989–1001 (2017).
Lo, W.-T. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-022-00730-w (2022).
Wang, H. et al. Mol. Cell 71, 343–351.e344 (2018).
Maffucci, T. & Falasca, M. Biochem. Soc. Trans. 42, 1378–1382 (2014).
Gaidarov, I., Smith, M. E., Domin, J. & Keen, J. H. Mol. Cell 7, 443–449 (2001).
Wheeler, M. & Domin, J. J. Cell. Physiol. 206, 586–593 (2006).
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Deng, P., Liu, JJ.G. Diverse activation mechanisms of PI3Ks. Nat Struct Mol Biol 29, 185–187 (2022). https://doi.org/10.1038/s41594-022-00744-4
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DOI: https://doi.org/10.1038/s41594-022-00744-4