Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

MISMATCH REPAIR

Tandem regulation of MutS activity by ATP and DNA during MMR initiation

Nature Structural & Molecular Biology volume 29, pages 5–7 (2022)Cite this article

Subjects

An elegant cryo-EM and biophysical study unveils the conformational changes of the E. coli MutS mismatch repair factor. This provides a nice follow-up to the recent report from the same group characterizing how MutS scans DNA without initiating repair on correctly base-paired DNA and recruits MutL upon encountering a mismatch.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Borsellini et al. report four cryo-EM structures of MutS in its apo form (grey) with ADP (orange), ATP or ATP analog (red) nucleotides.

References

  1. Jiricny, J. Cold Spring Harb. Perspect. Biol. 5, a012633 (2013).

    Article  Google Scholar 

  2. Obmolova, G., Ban, C., Hsieh, P. & Yang, W. Nature 407, 703–710 (2000).

    Article  CAS  Google Scholar 

  3. Lamers, M. H. et al. Nature 407, 711–717 (2000).

    Article  CAS  Google Scholar 

  4. Jeong, C. et al. Nat. Struct. Mol. Biol. 18, 379–385 (2011).

    Article  CAS  Google Scholar 

  5. Gorman, J. et al. Proc. Natl Acad. Sci. USA 109, E3074–E3083 (2012).

    Article  CAS  Google Scholar 

  6. Cho, W. K. et al. DNA. Structure 20, 1264–1274 (2012).

    Article  CAS  Google Scholar 

  7. Liu, J. et al. Nature 539, 583–587 (2016).

    Article  CAS  Google Scholar 

  8. Qiu, R. et al. Proc. Natl Acad. Sci. USA 112, 10914–10919 (2015).

    Article  CAS  Google Scholar 

  9. Fernandez-Leiro, R. et al. Nat. Struct. Mol. Biol. 28, 373–381 (2021).

    Article  CAS  Google Scholar 

  10. Groothuizen, F. S. et al. Elife 4, e06744 (2015).

    Article  Google Scholar 

  11. Borsellini, A., Kunetsky, V., Friedhoff, P. & Lamers, M. H. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-021-00707-1 (2022).

  12. Warren, J. J. et al. Mol. Cell 26, 579–592 (2007).

    Article  CAS  Google Scholar 

  13. Gupta, S., Gellert, M. & Yang, W. Nat. Struct. Mol. Biol. 19, 72–78 (2012).

    Article  CAS  Google Scholar 

  14. Banerjee, A., Yang, W., Karplus, M. & Verdine, G. L. Nature 434, 612–668 (2005).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

J.B.C. thanks the French National Research Agency for support (ANR-20-CE11-0026, ANR-17-CE12-0020 and ANR- 18-CE44-0008).

Author information

Authors and Affiliations

  1. Institute for Integrative Biology of the Cell (I2BC), Université Paris–Saclay, CEA, CNRS, Gif-sur-Yvette, France

    Jean Baptiste Charbonnier

Authors
  1. Jean Baptiste Charbonnier
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jean Baptiste Charbonnier.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Charbonnier, J.B. Tandem regulation of MutS activity by ATP and DNA during MMR initiation. Nat Struct Mol Biol 29, 5–7 (2022). https://doi.org/10.1038/s41594-021-00713-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41594-021-00713-3

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing