News & Views

NEUROTRANSMITTER RELEASE

Munc13 marks the spot

Super-resolution optical imaging of presynaptic terminals shows that a protein essential to all known forms of neurotransmitter release is clustered in small assemblies that likely correspond to release sites for synaptic vesicle fusion.

  • Subscribe to Nature Neuroscience for full access:

    $59

    Subscribe

Additional access options:

Already a subscriber?  Log in  now or  Register  for online access.

References

  1. 1.

    Katz, B. Science 173, 123–126 (1971).

  2. 2.

    Sakamoto, H. et al. Nat. Neurosci. https://doi.org/10.1038/s41593-017-0041-9 (2017).

  3. 3.

    Brenner, S. Genetics 77, 71–94 (1974).

  4. 4.

    Ahmed, S. et al. Biochem. J. 287, 995–999 (1992).

  5. 5.

    Imig, C. et al. Neuron 84, 416–431 (2014).

  6. 6.

    Rhee, J. S. et al. Cell 108, 121–133 (2002).

  7. 7.

    Junge, H. J. et al. Cell 118, 389–401 (2004).

  8. 8.

    Rothman, J. E., Krishnakumar, S. K., Grushin, K. & Pincet, F. FEBS Lett. 591, 3459–3480 (2017).

Download references

Author information

Affiliations

  1. Department of Biochemistry, Weill Cornell Medical College, New York, NY, USA

    • Timothy A. Ryan

Authors

  1. Search for Timothy A. Ryan in:

Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Timothy A. Ryan.