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Chemical biology

Fluorogenic chemically induced dimerization

Nature Methods volume 20, pages 1454–1455 (2023)Cite this article

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A new chemically induced dimerization (CID) pair exhibits fluorescence upon dimerization for the first time. Moreover, the CID pair is small and offers easily reversible dimerization that can be repeated multiple times.

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Fig. 1: Scheme of CATCHFIRE design and applications.

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Acknowledgements

W.W and J.S. are supported by the University of Michigan and National Institutes of Health grant DP2MH132939.

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Authors and Affiliations

  1. Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA

    Wenjing Wang & Jiaqi Shen

  2. Department of Chemistry, University of Michigan, Ann Arbor, MI, USA

    Wenjing Wang & Jiaqi Shen

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  1. Wenjing Wang
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  2. Jiaqi Shen
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Correspondence to Wenjing Wang.

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The authors declare no competing interests.

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Wang, W., Shen, J. Fluorogenic chemically induced dimerization. Nat Methods 20, 1454–1455 (2023). https://doi.org/10.1038/s41592-023-01989-7

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