In an era of expanding perioperative approaches for resectable non–small-cell lung cancer, new data demonstrate that dual neoadjuvant immunotherapy targeting PD-1 and LAG-3 is feasible; future analyses may enhance patient selection by identifying immune signatures predictive of response.
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M.D.S. previously served on the speakers’ bureau for Jazz Pharmaceuticals and has served on advisory board for Jazz Pharmaceuticals and AstraZeneca. C.M.L. has served on advisory boards for Amgen, AnHeart, Arrivent, AstraZeneca, Blueprints Medicine, BMS, Boehringer Ingelheim, Cepheid, D2G, Daiichi Sankyo, EMD Serono, Foundation Medicine, Genentech, Gilead, Guardant, Indupro, Janssen, Medscape, Novartis, Pfizer, Regeneron, Roche, Takeda and Tempus and has also served on a data and safety monitoring board for Janssen (uncompensated).
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Shields, M.D., Lovly, C.M. Refining neoadjuvant immunotherapy for resectable lung cancer. Nat Med (2024). https://doi.org/10.1038/s41591-024-03001-x
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DOI: https://doi.org/10.1038/s41591-024-03001-x