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Off-label use of artificial intelligence models in healthcare

Nature Medicine (2024)Cite this article

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In healthcare, many artificial intelligence models could be used in settings other than those for which they were approved. But such off-label use must include an empirical or mechanistic evaluation to ensure patient safety.

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References

  1. Wittich, C. M., Burkle, C. M. & Lanier, W. L. Mayo Clin. Proc. 87, 982–990 (2012).

  2. Futoma, J., Simons, M., Panch, T., Doshi-Velez, F. & Celi, L. A. Lancet Digit. Health 2, E489–E492 (2020).

  3. Sendak, M. P., Gao, M., Brajer, N. & Balu, S. npj Dig. Med. 3, 41 (2020).

    Article  Google Scholar 

  4. Sendak, M. et al. Proc. Mach. Learn. Res. 182, 1–19 (2022).

    Google Scholar 

  5. Walton, S. M. et al. Pharmacotherapy 28, 1443–1452 (2008).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Eguale, T. et al. JAMA Intern. Med. 176, 55–63 (2016).

    Article  PubMed  Google Scholar 

  7. Singh, K. et al. Ann. Am. Thorac. Soc. 18, 1129–1137 (2021).

    Article  MathSciNet  PubMed  PubMed Central  Google Scholar 

  8. Dussart, C., Pommier, P., Siranyan, V., Grelaud, G. & Dussart, S. J. Eval. Clin. Pract. 14, 718–720 (2008).

  9. Jercich, K. Healthcare IT News https://go.nature.com/49Xibyk (4 February 2021).

  10. Michard, F. & Vieillard-Baron, A. Intens. Care Med. 47, 254–255 (2021).

    Article  CAS  Google Scholar 

  11. Rudin, C. et al. Stat. Surv. 16, 1–85 (2022).

    Article  MathSciNet  Google Scholar 

  12. Lyons, P. G. et al. JAMA Intern. Med. 183, 611–612 (2023).

    Article  PubMed  Google Scholar 

  13. Song, J. W. & Chung, K. C. Plast. Reconstr. Surg. 126, 2234–2242 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Jones, A. E., Trzeciak, S. & Kline, J. A. Crit. Care Med. 37, 1649–1654 (2009).

    Article  PubMed  PubMed Central  Google Scholar 

  15. Yunusa, I. et al. Adv. Ther. 39, 1993–2008 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

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Authors and Affiliations

  1. Division of Computer Science and Engineering, University of Michigan, Ann Arbor, MI, USA

    Meera Krishnamoorthy & Jenna Wiens

  2. Division of Pulmonary and Critical Care, Michigan Medicine, Ann Arbor, MI, USA

    Michael W. Sjoding

Authors
  1. Meera Krishnamoorthy
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  2. Michael W. Sjoding
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  3. Jenna Wiens
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Corresponding author

Correspondence to Jenna Wiens.

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Competing interests

As co-inventor, M.W.S. has received royalties from software licensed by the University of Michigan to AirStrip Technologies, which processes chest X-rays to identify acute respiratory distress syndrome.

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Krishnamoorthy, M., Sjoding, M.W. & Wiens, J. Off-label use of artificial intelligence models in healthcare. Nat Med (2024). https://doi.org/10.1038/s41591-024-02870-6

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