This study reveals that the production of cobalamin and succinyl-CoA is increased in the anal microbiome of patients with precancerous anal lesions. Testing for these two metabolites significantly improves diagnostic accuracy over standard cytology screening, which suggests potential for enhanced screening strategies for anal cancer.
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References
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This is a summary of: Serrano-Villar, S. et al. Microbiome-derived cobalamin and succinyl-CoA as biomarkers for improved screening of anal cancer. Nat. Med. https://doi.org/10.1038/s41591-023-02407-3 (2023).
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How the microbiome can help detect precancerous lesions and prevent anal cancer. Nat Med 29, 1619–1620 (2023). https://doi.org/10.1038/s41591-023-02421-5
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DOI: https://doi.org/10.1038/s41591-023-02421-5