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Inflammasomes

Divergent mechanisms of inflammasome activation in neutrophil early response and inflammation

Nature Immunology volume 24, pages 1970–1971 (2023)Cite this article

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S100A8 and S100A9 are cytosolic alarmins with autocrine functions that facilitate neutrophil recruitment. Rapid, transient gasdermin-D pore formation is now shown to mediate secretion of these proteins in response to E-selectin without driving pyroptosis.

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Fig. 1: Inflammasome functions in neutrophil secretory responses.

References

  1. Ley, K. et al. Sci. Immunol. 3, eaat4579 (2018).

    Article  PubMed  Google Scholar 

  2. Zarbock, A. & Ley, K. Microcirculation 16, 31–42 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Hidalgo, A., Peired, A. J., Wild, M., Vestweber, D. & Frenette, P. S. Immunity 26, 477–489 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Pruenster, M. et al. Nat. Immunol. https://doi.org/10.1038/s41590-023-01656-1 (2023).

    Article  PubMed  Google Scholar 

  5. Pruenster, M. et al. Nat. Commun. 6, 6915 (2015).

    Article  CAS  PubMed  Google Scholar 

  6. Brydges, S. D. et al. J. Clin. Invest. 123, 4695–4705 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Strowig, T., Henao-Mejia, J., Elinav, E. & Flavell, R. Nature 481, 278–286 (2012).

    Article  CAS  PubMed  Google Scholar 

  8. Karmakar, M. et al. Nat. Commun. 11, 2212 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Jorch, S. K. et al. J. Allergy Clin. Immunol. 152, 230–243 (2023).

    Article  CAS  PubMed  Google Scholar 

  10. Johnson, J. L. et al. Front. Cell Infect. Microbiol. 7, 507 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

The author is supported by US Public Health Service grants R01HL088256, P01HL152958 and R01DK110162.

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  1. Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA, USA

    Sergio D. Catz

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  1. Sergio D. Catz
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Correspondence to Sergio D. Catz.

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The author declares no competing interests.

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Catz, S.D. Divergent mechanisms of inflammasome activation in neutrophil early response and inflammation. Nat Immunol 24, 1970–1971 (2023). https://doi.org/10.1038/s41590-023-01684-x

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