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Treg cells

IL-27 gives a good gut feeling about immune regulation

Nature Immunology volume 24, pages 1972–1973 (2023)Cite this article

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Regulatory T (Treg) cells maintain the balance between immune protection and pathology. Research has now found that intestinal Treg cells produce IL-27 to restrain TH17 cell-mediated immune responses, effectively restricting autoimmune inflammation and limiting T cell responses to certain gut pathogens.

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Fig. 1: Gut inflammation drives Treg production of the immunoregulatory cytokine IL-27.

References

  1. Josefowicz, S. Z., Lu, L.-F. & Rudensky, A. Y. Annu. Rev. Immunol. 30, 531–564 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Lin, C.-H. et al. Nat. Immunol. https://doi.org/10.1038/s41590-023-01667-y (2023).

    Article  PubMed  Google Scholar 

  3. Panduro, M., Benoist, C. & Mathis, D. Annu. Rev. Immunol. 34, 609–633 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Yoshida, H. & Hunter, C. A. Annu. Rev. Immunol. 33, 417–443 (2015).

    Article  CAS  PubMed  Google Scholar 

  5. Stumhofer, J. S. et al. Nat. Immunol. 8, 1363–1371 (2007).

    Article  CAS  PubMed  Google Scholar 

  6. Hibbert, L., Pflanz, S., De Waal Malefyt, R. & Kastelein, R. A. J. Interferon Cytokine Res. 23, 513–522 (2003).

    Article  CAS  PubMed  Google Scholar 

  7. Zhou, L. et al. Nat. Immunol. 8, 967–974 (2007).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Immunobiology, Yale University, New Haven, CT, USA

    Emily R. Siniscalco & Joe Craft

  2. Department of Internal Medicine, Yale University, New Haven, CT, USA

    Joe Craft

Authors
  1. Emily R. Siniscalco
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  2. Joe Craft
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Correspondence to Emily R. Siniscalco or Joe Craft.

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The authors declare no competing interests.

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Siniscalco, E.R., Craft, J. IL-27 gives a good gut feeling about immune regulation. Nat Immunol 24, 1972–1973 (2023). https://doi.org/10.1038/s41590-023-01683-y

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