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Antigen presentation

Unconventionally presenting an unconventional viral peptide

Nature Immunology volume 24, pages 1787–1789 (2023)Cite this article

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Hogan et al. identify a co-immunodominant influenza peptide presented in mice by MHC-E, a nonclassical class I molecule. Notably, the peptide derives from a 16-residue alternative reading frame translated by leaky ribosome scanning of the M1 mRNA and is recognized by conventional CD8+ T cells.

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Fig. 1: Model of cryptic M-SL9 peptide synthesis and MHC-E presentation in influenza virus–infected cells.

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Acknowledgements

The authors are supported by the Division of Intramural Research, US National Institute of Allergy and Infectious Diseases.

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Authors and Affiliations

  1. Cellular Biology Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA

    Jaroslav Holly & Jonathan W. Yewdell

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  1. Jaroslav Holly
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  2. Jonathan W. Yewdell
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Correspondence to Jonathan W. Yewdell.

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The authors declare no competing interests.

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Holly, J., Yewdell, J.W. Unconventionally presenting an unconventional viral peptide. Nat Immunol 24, 1787–1789 (2023). https://doi.org/10.1038/s41590-023-01652-5

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