Many immune cell subsets move in an amoeboid fashion and do not require strong adhesive interactions with their surrounding when moving through interstitial tissue spaces. In stark contrast, we show that mast cells critically depend on integrin-mediated adhesion and interactions with the extracellular matrix to enable slow migration and site-specific positioning in tissues.
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References
Lämmermann, T. et al. Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature 453, 51–55 (2008). This paper reports that integrin receptors are dispensable for the 3D migration of several immune cell types.
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This is a summary of: Kaltenbach, L. et al. Slow integrin-dependent migration organizes networks of tissue-resident mast cells. Nat. Immunol. https://doi.org/10.1038/s41590-023-01493-2 (2023).
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Mast cell migration and organization in tissues depend on integrin–ECM interactions. Nat Immunol 24, 899–900 (2023). https://doi.org/10.1038/s41590-023-01494-1
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DOI: https://doi.org/10.1038/s41590-023-01494-1
