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HUMORAL IMMUNITY

Complement-in’ the germinal center response

Nature Immunology volume 22, pages 673–674 (2021)Cite this article

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B cells rewire complement for optimal germinal center responses. When B cell C3 activity is limited, germinal centers collapse and outputs are impaired.

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Fig. 1: The germinal center B cell response to complement is specific and required for normal activity.

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Acknowledgements

D.M.T. is supported by an Investigator Grant (1175411) from the National Health and Medical Research Council (NHMRC), Australia. This work was also supported by NHMRC Ideas Grants awarded to M.J.R. (1185294) and I.Q. (2002393).

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Authors and Affiliations

  1. Department of Immunology and Pathology, Monash University, Melbourne, Victoria, Australia

    Marcus James Robinson, Isaak Quast & David Mathew Tarlinton

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  1. Marcus James Robinson
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  2. Isaak Quast
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  3. David Mathew Tarlinton
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Correspondence to David Mathew Tarlinton.

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Robinson, M.J., Quast, I. & Tarlinton, D.M. Complement-in’ the germinal center response. Nat Immunol 22, 673–674 (2021). https://doi.org/10.1038/s41590-021-00946-w

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