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LYMPHOCYTE ACTIVATION

CD8+ T cells have commitment issues

Nature Immunology volume 19, pages 797–799 (2018)Cite this article

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T cell activation is ‘digital’: exhaustive single-cell analysis shows that only the proportion of cells that cross the activation threshold is reduced when the affinity of the TCR for its ligand is reduced.

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Fig. 1: Population and single-cell views of CD8+ T cell responses to pMHC ligands of various affinities.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

    Renu Balyan, Joanna Brzostek & Nicholas R. J. Gascoigne

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  1. Renu Balyan
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  2. Joanna Brzostek
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  3. Nicholas R. J. Gascoigne
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Correspondence to Nicholas R. J. Gascoigne.

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The authors declare no competing interests.

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Balyan, R., Brzostek, J. & Gascoigne, N.R.J. CD8+ T cells have commitment issues. Nat Immunol 19, 797–799 (2018). https://doi.org/10.1038/s41590-018-0169-0

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